Autologous Hematopoietic Cell Transplant as an Effective Treatment Modality for Systemic Sclerosis and Multiple Myeloma
Hamda Memon,1 Ricardo Parrondo,2 Julianna Schreurs,2 Ernesto Ayala,2 Madiha Iqbal2 1Department of Family Medicine, Geisinger Health in Wilkes Barre, Wilkes Barre, Pennsylvania, USA; 2Division of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, USACorrespondence: Madiha Iqbal, Department...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-01-01
|
| Series: | Journal of Blood Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/autologous-hematopoietic-cell-transplant-as-an-effective-treatment-mod-peer-reviewed-fulltext-article-JBM |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841555951765684224 |
|---|---|
| author | Memon H Parrondo R Schreurs J Ayala E Iqbal M |
| author_facet | Memon H Parrondo R Schreurs J Ayala E Iqbal M |
| author_sort | Memon H |
| collection | DOAJ |
| description | Hamda Memon,1 Ricardo Parrondo,2 Julianna Schreurs,2 Ernesto Ayala,2 Madiha Iqbal2 1Department of Family Medicine, Geisinger Health in Wilkes Barre, Wilkes Barre, Pennsylvania, USA; 2Division of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, USACorrespondence: Madiha Iqbal, Department of Medicine,Division of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic, 4500 San Pablo road, Jacksonville, FL, 32224, USA, Email Iqbal.madiha@mayo.eduAbstract: Systemic sclerosis (SSc) is a multi-system disease characterized by a dysregulated immune system. Autologous hematopoietic cell transplantation (AHCT) is the only treatment that has been shown to confer significant benefit in controlling disease and improving survival for patients with SSc. A diagnosis of multiple myeloma (MM) after the diagnosis of SSc is rare and optimal treatment in such cases remains unclear. We here report a case of a female patient who was diagnosed with MM while she was undergoing evaluation for AHCT due to SSc. A novel conditioning regimen for AHCT, with therapeutic efficacy in SSc and MM was offered to the patient, resulting in long term remission of both diseases.Keywords: systemic sclerosis, autologous hematopoietic cell transplantation, multiple myeloma |
| format | Article |
| id | doaj-art-138781cc43034856b00ac7e7033c5ff2 |
| institution | Kabale University |
| issn | 1179-2736 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Blood Medicine |
| spelling | doaj-art-138781cc43034856b00ac7e7033c5ff22025-01-07T16:42:40ZengDove Medical PressJournal of Blood Medicine1179-27362025-01-01Volume 1671398973Autologous Hematopoietic Cell Transplant as an Effective Treatment Modality for Systemic Sclerosis and Multiple MyelomaMemon HParrondo RSchreurs JAyala EIqbal MHamda Memon,1 Ricardo Parrondo,2 Julianna Schreurs,2 Ernesto Ayala,2 Madiha Iqbal2 1Department of Family Medicine, Geisinger Health in Wilkes Barre, Wilkes Barre, Pennsylvania, USA; 2Division of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, USACorrespondence: Madiha Iqbal, Department of Medicine,Division of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic, 4500 San Pablo road, Jacksonville, FL, 32224, USA, Email Iqbal.madiha@mayo.eduAbstract: Systemic sclerosis (SSc) is a multi-system disease characterized by a dysregulated immune system. Autologous hematopoietic cell transplantation (AHCT) is the only treatment that has been shown to confer significant benefit in controlling disease and improving survival for patients with SSc. A diagnosis of multiple myeloma (MM) after the diagnosis of SSc is rare and optimal treatment in such cases remains unclear. We here report a case of a female patient who was diagnosed with MM while she was undergoing evaluation for AHCT due to SSc. A novel conditioning regimen for AHCT, with therapeutic efficacy in SSc and MM was offered to the patient, resulting in long term remission of both diseases.Keywords: systemic sclerosis, autologous hematopoietic cell transplantation, multiple myelomahttps://www.dovepress.com/autologous-hematopoietic-cell-transplant-as-an-effective-treatment-mod-peer-reviewed-fulltext-article-JBMsystemic sclerosisautologous hematopoietic cell transplantationmultiple myeloma |
| spellingShingle | Memon H Parrondo R Schreurs J Ayala E Iqbal M Autologous Hematopoietic Cell Transplant as an Effective Treatment Modality for Systemic Sclerosis and Multiple Myeloma Journal of Blood Medicine systemic sclerosis autologous hematopoietic cell transplantation multiple myeloma |
| title | Autologous Hematopoietic Cell Transplant as an Effective Treatment Modality for Systemic Sclerosis and Multiple Myeloma |
| title_full | Autologous Hematopoietic Cell Transplant as an Effective Treatment Modality for Systemic Sclerosis and Multiple Myeloma |
| title_fullStr | Autologous Hematopoietic Cell Transplant as an Effective Treatment Modality for Systemic Sclerosis and Multiple Myeloma |
| title_full_unstemmed | Autologous Hematopoietic Cell Transplant as an Effective Treatment Modality for Systemic Sclerosis and Multiple Myeloma |
| title_short | Autologous Hematopoietic Cell Transplant as an Effective Treatment Modality for Systemic Sclerosis and Multiple Myeloma |
| title_sort | autologous hematopoietic cell transplant as an effective treatment modality for systemic sclerosis and multiple myeloma |
| topic | systemic sclerosis autologous hematopoietic cell transplantation multiple myeloma |
| url | https://www.dovepress.com/autologous-hematopoietic-cell-transplant-as-an-effective-treatment-mod-peer-reviewed-fulltext-article-JBM |
| work_keys_str_mv | AT memonh autologoushematopoieticcelltransplantasaneffectivetreatmentmodalityforsystemicsclerosisandmultiplemyeloma AT parrondor autologoushematopoieticcelltransplantasaneffectivetreatmentmodalityforsystemicsclerosisandmultiplemyeloma AT schreursj autologoushematopoieticcelltransplantasaneffectivetreatmentmodalityforsystemicsclerosisandmultiplemyeloma AT ayalae autologoushematopoieticcelltransplantasaneffectivetreatmentmodalityforsystemicsclerosisandmultiplemyeloma AT iqbalm autologoushematopoieticcelltransplantasaneffectivetreatmentmodalityforsystemicsclerosisandmultiplemyeloma |