Orychophragvioline A, a Novel Alkaloid Isolated from <i>Orychophragmus violaceus</i> with Anti-Cervical Cancer Activity
A new alkaloid (orychophragvioline A) and nine known compounds were yielded from the seeds of <i>Orychophragmus violaceus</i>. Their structures were determined by various spectroscopic techniques and single-crystal X-ray diffraction. Orychophragvioline A is a rare alkaloid with an unusua...
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MDPI AG
2025-04-01
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| author | Ya Li Tonghe Liu Guangjie Pan Yihang Li Guoxu Ma Yong Hou Nailiang Zhu Xudong Xu |
| author_facet | Ya Li Tonghe Liu Guangjie Pan Yihang Li Guoxu Ma Yong Hou Nailiang Zhu Xudong Xu |
| author_sort | Ya Li |
| collection | DOAJ |
| description | A new alkaloid (orychophragvioline A) and nine known compounds were yielded from the seeds of <i>Orychophragmus violaceus</i>. Their structures were determined by various spectroscopic techniques and single-crystal X-ray diffraction. Orychophragvioline A is a rare alkaloid with an unusual 1-methyl-4-phenyl-2,3-diketopiperazine skeleton connected with a guanidine group via an amide bond. The results of antitumor tests in vitro showed that it exhibited prominent cytotoxicity against Hela cells with an IC<sub>50</sub> value of 11.95 ± 1.52 μM. Further investigations suggested that it significantly inhibited cellular proliferation, migration, and invasion in a dose-dependent manner, thus inducing the apoptosis of Hela cells. These findings indicate that orychophragvioline A can be regarded as a potential natural leading compound against cervical cancer. |
| format | Article |
| id | doaj-art-13877b425dc2455e9bdd0beed3e9d2bd |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj-art-13877b425dc2455e9bdd0beed3e9d2bd2025-08-20T03:13:48ZengMDPI AGMolecules1420-30492025-04-01308175910.3390/molecules30081759Orychophragvioline A, a Novel Alkaloid Isolated from <i>Orychophragmus violaceus</i> with Anti-Cervical Cancer ActivityYa Li0Tonghe Liu1Guangjie Pan2Yihang Li3Guoxu Ma4Yong Hou5Nailiang Zhu6Xudong Xu7Department of Gynecologic Cancer, Beijing Arion Cancer Center, Beijing 100070, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, ChinaCollege of Chinese Medicine Material, Jilin Agricultural University, Changchun 130118, ChinaYunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Jinghong 666100, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, ChinaA new alkaloid (orychophragvioline A) and nine known compounds were yielded from the seeds of <i>Orychophragmus violaceus</i>. Their structures were determined by various spectroscopic techniques and single-crystal X-ray diffraction. Orychophragvioline A is a rare alkaloid with an unusual 1-methyl-4-phenyl-2,3-diketopiperazine skeleton connected with a guanidine group via an amide bond. The results of antitumor tests in vitro showed that it exhibited prominent cytotoxicity against Hela cells with an IC<sub>50</sub> value of 11.95 ± 1.52 μM. Further investigations suggested that it significantly inhibited cellular proliferation, migration, and invasion in a dose-dependent manner, thus inducing the apoptosis of Hela cells. These findings indicate that orychophragvioline A can be regarded as a potential natural leading compound against cervical cancer.https://www.mdpi.com/1420-3049/30/8/1759orychophragvioline Anatural productanti-cervical cancernew compound |
| spellingShingle | Ya Li Tonghe Liu Guangjie Pan Yihang Li Guoxu Ma Yong Hou Nailiang Zhu Xudong Xu Orychophragvioline A, a Novel Alkaloid Isolated from <i>Orychophragmus violaceus</i> with Anti-Cervical Cancer Activity Molecules orychophragvioline A natural product anti-cervical cancer new compound |
| title | Orychophragvioline A, a Novel Alkaloid Isolated from <i>Orychophragmus violaceus</i> with Anti-Cervical Cancer Activity |
| title_full | Orychophragvioline A, a Novel Alkaloid Isolated from <i>Orychophragmus violaceus</i> with Anti-Cervical Cancer Activity |
| title_fullStr | Orychophragvioline A, a Novel Alkaloid Isolated from <i>Orychophragmus violaceus</i> with Anti-Cervical Cancer Activity |
| title_full_unstemmed | Orychophragvioline A, a Novel Alkaloid Isolated from <i>Orychophragmus violaceus</i> with Anti-Cervical Cancer Activity |
| title_short | Orychophragvioline A, a Novel Alkaloid Isolated from <i>Orychophragmus violaceus</i> with Anti-Cervical Cancer Activity |
| title_sort | orychophragvioline a a novel alkaloid isolated from i orychophragmus violaceus i with anti cervical cancer activity |
| topic | orychophragvioline A natural product anti-cervical cancer new compound |
| url | https://www.mdpi.com/1420-3049/30/8/1759 |
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