Orychophragvioline A, a Novel Alkaloid Isolated from <i>Orychophragmus violaceus</i> with Anti-Cervical Cancer Activity
A new alkaloid (orychophragvioline A) and nine known compounds were yielded from the seeds of <i>Orychophragmus violaceus</i>. Their structures were determined by various spectroscopic techniques and single-crystal X-ray diffraction. Orychophragvioline A is a rare alkaloid with an unusua...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/8/1759 |
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| Summary: | A new alkaloid (orychophragvioline A) and nine known compounds were yielded from the seeds of <i>Orychophragmus violaceus</i>. Their structures were determined by various spectroscopic techniques and single-crystal X-ray diffraction. Orychophragvioline A is a rare alkaloid with an unusual 1-methyl-4-phenyl-2,3-diketopiperazine skeleton connected with a guanidine group via an amide bond. The results of antitumor tests in vitro showed that it exhibited prominent cytotoxicity against Hela cells with an IC<sub>50</sub> value of 11.95 ± 1.52 μM. Further investigations suggested that it significantly inhibited cellular proliferation, migration, and invasion in a dose-dependent manner, thus inducing the apoptosis of Hela cells. These findings indicate that orychophragvioline A can be regarded as a potential natural leading compound against cervical cancer. |
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| ISSN: | 1420-3049 |