From the Cytoplasm into the Nucleus—Hepatitis B Virus Travel and Genome Repair
Hepatitis B virus (HBV) is a major global health concern, affecting millions of people worldwide. HBV is part of the hepadnaviridae family and one of the primary causes of acute and chronic liver infections, leading to conditions such as cirrhosis and hepatocellular carcinoma (HCC). Understanding th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/1/157 |
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| _version_ | 1832587831734697984 |
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| author | Johan Ringlander Gustaf E. Rydell Michael Kann |
| author_facet | Johan Ringlander Gustaf E. Rydell Michael Kann |
| author_sort | Johan Ringlander |
| collection | DOAJ |
| description | Hepatitis B virus (HBV) is a major global health concern, affecting millions of people worldwide. HBV is part of the hepadnaviridae family and one of the primary causes of acute and chronic liver infections, leading to conditions such as cirrhosis and hepatocellular carcinoma (HCC). Understanding the intracellular transport and genome repair mechanisms of HBV is crucial for developing new drugs, which—in combination with immune modulators—may contribute to potential cures. This review will explore the current knowledge of HBV intracytoplasmic and nuclear transport, as well as genome repair processes, while drawing comparisons to other viruses with nuclear replication. |
| format | Article |
| id | doaj-art-1386e4870365436eb7063ade4f6679b6 |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-1386e4870365436eb7063ade4f6679b62025-01-24T13:42:51ZengMDPI AGMicroorganisms2076-26072025-01-0113115710.3390/microorganisms13010157From the Cytoplasm into the Nucleus—Hepatitis B Virus Travel and Genome RepairJohan Ringlander0Gustaf E. Rydell1Michael Kann2Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, SwedenDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, SwedenDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, SwedenHepatitis B virus (HBV) is a major global health concern, affecting millions of people worldwide. HBV is part of the hepadnaviridae family and one of the primary causes of acute and chronic liver infections, leading to conditions such as cirrhosis and hepatocellular carcinoma (HCC). Understanding the intracellular transport and genome repair mechanisms of HBV is crucial for developing new drugs, which—in combination with immune modulators—may contribute to potential cures. This review will explore the current knowledge of HBV intracytoplasmic and nuclear transport, as well as genome repair processes, while drawing comparisons to other viruses with nuclear replication.https://www.mdpi.com/2076-2607/13/1/157hepatitis B viruscore protein phosphorylationcapsidintracellular transportnuclear importnuclear pore complex (NPC) |
| spellingShingle | Johan Ringlander Gustaf E. Rydell Michael Kann From the Cytoplasm into the Nucleus—Hepatitis B Virus Travel and Genome Repair Microorganisms hepatitis B virus core protein phosphorylation capsid intracellular transport nuclear import nuclear pore complex (NPC) |
| title | From the Cytoplasm into the Nucleus—Hepatitis B Virus Travel and Genome Repair |
| title_full | From the Cytoplasm into the Nucleus—Hepatitis B Virus Travel and Genome Repair |
| title_fullStr | From the Cytoplasm into the Nucleus—Hepatitis B Virus Travel and Genome Repair |
| title_full_unstemmed | From the Cytoplasm into the Nucleus—Hepatitis B Virus Travel and Genome Repair |
| title_short | From the Cytoplasm into the Nucleus—Hepatitis B Virus Travel and Genome Repair |
| title_sort | from the cytoplasm into the nucleus hepatitis b virus travel and genome repair |
| topic | hepatitis B virus core protein phosphorylation capsid intracellular transport nuclear import nuclear pore complex (NPC) |
| url | https://www.mdpi.com/2076-2607/13/1/157 |
| work_keys_str_mv | AT johanringlander fromthecytoplasmintothenucleushepatitisbvirustravelandgenomerepair AT gustaferydell fromthecytoplasmintothenucleushepatitisbvirustravelandgenomerepair AT michaelkann fromthecytoplasmintothenucleushepatitisbvirustravelandgenomerepair |