Mechanisms of hepatitis B virus X protein in progression and drug resistance of hepatocellular carcinoma
Hepatocellular carcinoma (HCC), as a highly prevalent primary liver malignancy, poses a significant global public health challenge. Its persistently high incidence and mortality rates severely impact patients' quality of life and life expectancy. Although chemotherapy and targeted therapies are...
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Lanzhou University Press
2025-06-01
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| Series: | 生物医学转化 |
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| Online Access: | http://swyxzh.ijournals.cn/swyxzh/article/html/20250207?st=article_issue |
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| author | Zhou Ping Zhu Fan |
| author_facet | Zhou Ping Zhu Fan |
| author_sort | Zhou Ping |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC), as a highly prevalent primary liver malignancy, poses a significant global public health challenge. Its persistently high incidence and mortality rates severely impact patients' quality of life and life expectancy. Although chemotherapy and targeted therapies are commonly administered to patients with advanced HCC, their efficacy is often limited by the emergence of drug resistance. Chronic infection with hepatitis B virus (HBV), encoded by the X region of the HBV genome, plays a critical role in the development of HCC. HBx is a multifunctional regulatory protein that not only promotes the malignant transformation of normal hepatocytes but also contributes significantly to the mechanisms underlying drug resistance in HCC. Recent studies have demonstrated that HBx interferes with multiple molecular pathways, including apoptosis, autophagy, epigenetic modification, and drug efflux, thereby facilitating treatment failure.This review focuses on the molecular mechanisms by which HBx promotes HCC progression and mediates drug resistance, aiming to offer novel therapeutic targets and inform future treatment strategies for drug-resistant HBVrelated HCC. |
| format | Article |
| id | doaj-art-13864884f04d4c50b0372c994d8a0fb0 |
| institution | Kabale University |
| issn | 2096-8965 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Lanzhou University Press |
| record_format | Article |
| series | 生物医学转化 |
| spelling | doaj-art-13864884f04d4c50b0372c994d8a0fb02025-08-20T03:33:26ZzhoLanzhou University Press生物医学转化2096-89652025-06-0162394710.12287/j.issn.2096-8965.20250206Mechanisms of hepatitis B virus X protein in progression and drug resistance of hepatocellular carcinomaZhou Ping0Zhu Fan1State Key Laboratory of Virology and Biosafety, School of Basic Medical Sciences, Wuhan University, Wuhan 430071 , Hubei, ChinaState Key Laboratory of Virology and Biosafety, School of Basic Medical Sciences, Wuhan University, Wuhan 430071 , Hubei, China; Hubei Province Key Laboratory of Allergy & Immunology, Wuhan University, Wuhan 430071 , Hubei, ChinaHepatocellular carcinoma (HCC), as a highly prevalent primary liver malignancy, poses a significant global public health challenge. Its persistently high incidence and mortality rates severely impact patients' quality of life and life expectancy. Although chemotherapy and targeted therapies are commonly administered to patients with advanced HCC, their efficacy is often limited by the emergence of drug resistance. Chronic infection with hepatitis B virus (HBV), encoded by the X region of the HBV genome, plays a critical role in the development of HCC. HBx is a multifunctional regulatory protein that not only promotes the malignant transformation of normal hepatocytes but also contributes significantly to the mechanisms underlying drug resistance in HCC. Recent studies have demonstrated that HBx interferes with multiple molecular pathways, including apoptosis, autophagy, epigenetic modification, and drug efflux, thereby facilitating treatment failure.This review focuses on the molecular mechanisms by which HBx promotes HCC progression and mediates drug resistance, aiming to offer novel therapeutic targets and inform future treatment strategies for drug-resistant HBVrelated HCC.http://swyxzh.ijournals.cn/swyxzh/article/html/20250207?st=article_issuehepatitis b virus x proteinhepatocellular carcinomadrug resistancemolecular mechanisms |
| spellingShingle | Zhou Ping Zhu Fan Mechanisms of hepatitis B virus X protein in progression and drug resistance of hepatocellular carcinoma 生物医学转化 hepatitis b virus x protein hepatocellular carcinoma drug resistance molecular mechanisms |
| title | Mechanisms of hepatitis B virus X protein in progression and drug resistance of hepatocellular carcinoma |
| title_full | Mechanisms of hepatitis B virus X protein in progression and drug resistance of hepatocellular carcinoma |
| title_fullStr | Mechanisms of hepatitis B virus X protein in progression and drug resistance of hepatocellular carcinoma |
| title_full_unstemmed | Mechanisms of hepatitis B virus X protein in progression and drug resistance of hepatocellular carcinoma |
| title_short | Mechanisms of hepatitis B virus X protein in progression and drug resistance of hepatocellular carcinoma |
| title_sort | mechanisms of hepatitis b virus x protein in progression and drug resistance of hepatocellular carcinoma |
| topic | hepatitis b virus x protein hepatocellular carcinoma drug resistance molecular mechanisms |
| url | http://swyxzh.ijournals.cn/swyxzh/article/html/20250207?st=article_issue |
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