Repositioning Perindopril for Mitigation of Methotrexate-Induced Hepatotoxicity in Rats

Repositioning Perindopril for Mitigation of Methotrexate-Induced Hepatotoxicity in Rats

<b>Background/Objectives:</b> Methotrexate is a folate antagonist that has proven efficacy as an anticancer and immunomodulatory agent. However, the possible incidence of overt hepatotoxicity represents a challenge for its clinical use. Up till now, no single remedy has been considered a...

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Bibliographic Details
Main Authors: Hanan Abdelmawgoud Atia, Hemat A. Elariny, Marwa H. Abdallah, Amany M. Khalifa, Remon S. Estfanous, Maaly A. Abd Elmaaboud, Ahmed M. Kabel
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceuticals
Subjects:
perindopril
methotrexate
hepatotoxicity
inflammatory cascade
HMGB1
rats
Online Access:https://www.mdpi.com/1424-8247/18/3/358
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