Inhibition of nitric oxide synthase activity and chemokine (CXCL12) supplementation can improve hematopoietic reconstitution in mice lethally irradiated by 60Co gamma radiation

Inhibition of nitric oxide synthase activity and chemokine (CXCL12) supplementation can improve hematopoietic reconstitution in mice lethally irradiated by 60Co gamma radiation

Reduction of nitric oxide (NO) production is related to increased survival in some models of infection and ionizing radiation (IR) exposure. The work used lethally irradiated (60Co, 8Gy) C57Bl6j mice, treated or not with aminoguanidine (AG), an inhibitor of an isoform of nitric oxide synthase (iNOS)...

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Bibliographic Details
Main Authors: Daniel Perez Vieira, Andrés Jimenez Galisteo Jr., Heitor Franco de Andrade Jr.
Format: Article
Language:English
Published: Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) 2019-01-01
Series:Brazilian Journal of Radiation Sciences
Subjects:
nitric oxide
cxcl12
hematopoiesis
Online Access:https://bjrs.org.br/revista/index.php/REVISTA/article/view/789
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