Primary Dural Lymphoma Mimicking En Plaque Cerebellopontine Angle Meningioma

Primary dural lymphoma (PDL) usually arises from the calvarial dura without the brain parenchyma or systemic involvement and thus may not be considered as a typical form of primary CNS lymphoma (PCNSL). It is exceedingly rare. When it occurs, it might not be suspected as a primary diagnosis on clini...

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Main Authors: Mei Xu, Ashish Bains, Yuan Rong
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Case Reports in Pathology
Online Access:http://dx.doi.org/10.1155/2021/2845995
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author Mei Xu
Ashish Bains
Yuan Rong
author_facet Mei Xu
Ashish Bains
Yuan Rong
author_sort Mei Xu
collection DOAJ
description Primary dural lymphoma (PDL) usually arises from the calvarial dura without the brain parenchyma or systemic involvement and thus may not be considered as a typical form of primary CNS lymphoma (PCNSL). It is exceedingly rare. When it occurs, it might not be suspected as a primary diagnosis on clinical and radiologic findings. We present a PDL case that occurs at the cerebellopontine (CP) angle mimicking en plaque meningioma. The tumor histopathology showed a lymphoproliferative disorder immunophenotypically consistent with a low-grade marginal zone lymphoma. Bone marrow and systemic involvements were not identified, and a diagnosis of PDL was established. As a residual tumor at the CP angle was inaccessible to surgery, postoperative radiation therapy was performed. No recurrence was found at 15-month follow-up. PDLs are mostly indolent and have a good prognosis. There is no doubt that the most important differential diagnosis is meningioma. Furthermore, the present case emphasizes the necessity of an intraoperative consultation and knowledge of this rare yet essential form of PCNSL so that appropriate studies can be ordered.
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spelling doaj-art-1355cb64d34440869aba6a7c22c1ac702025-02-03T01:27:06ZengWileyCase Reports in Pathology2090-67812090-679X2021-01-01202110.1155/2021/28459952845995Primary Dural Lymphoma Mimicking En Plaque Cerebellopontine Angle MeningiomaMei Xu0Ashish Bains1Yuan Rong2Department of Biomedical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USADepartment of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USADepartment of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USAPrimary dural lymphoma (PDL) usually arises from the calvarial dura without the brain parenchyma or systemic involvement and thus may not be considered as a typical form of primary CNS lymphoma (PCNSL). It is exceedingly rare. When it occurs, it might not be suspected as a primary diagnosis on clinical and radiologic findings. We present a PDL case that occurs at the cerebellopontine (CP) angle mimicking en plaque meningioma. The tumor histopathology showed a lymphoproliferative disorder immunophenotypically consistent with a low-grade marginal zone lymphoma. Bone marrow and systemic involvements were not identified, and a diagnosis of PDL was established. As a residual tumor at the CP angle was inaccessible to surgery, postoperative radiation therapy was performed. No recurrence was found at 15-month follow-up. PDLs are mostly indolent and have a good prognosis. There is no doubt that the most important differential diagnosis is meningioma. Furthermore, the present case emphasizes the necessity of an intraoperative consultation and knowledge of this rare yet essential form of PCNSL so that appropriate studies can be ordered.http://dx.doi.org/10.1155/2021/2845995
spellingShingle Mei Xu
Ashish Bains
Yuan Rong
Primary Dural Lymphoma Mimicking En Plaque Cerebellopontine Angle Meningioma
Case Reports in Pathology
title Primary Dural Lymphoma Mimicking En Plaque Cerebellopontine Angle Meningioma
title_full Primary Dural Lymphoma Mimicking En Plaque Cerebellopontine Angle Meningioma
title_fullStr Primary Dural Lymphoma Mimicking En Plaque Cerebellopontine Angle Meningioma
title_full_unstemmed Primary Dural Lymphoma Mimicking En Plaque Cerebellopontine Angle Meningioma
title_short Primary Dural Lymphoma Mimicking En Plaque Cerebellopontine Angle Meningioma
title_sort primary dural lymphoma mimicking en plaque cerebellopontine angle meningioma
url http://dx.doi.org/10.1155/2021/2845995
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