Bone Marrow Aplasia and Neutropenic Fever Following Azathioprine Dose Escalation in a TPMT-Deficient Patient with Crohn’s Disease and Psoriatic Arthritis—A CARE–Compliant Case

Bone Marrow Aplasia and Neutropenic Fever Following Azathioprine Dose Escalation in a TPMT-Deficient Patient with Crohn’s Disease and Psoriatic Arthritis—A CARE–Compliant Case

<b>Background:</b> Myelotoxicity, usually manifested by moderate leukopenia (particularly neutropenia), is a well-known adverse drug reaction to azathioprine (AZA) therapy. Thiopurine methyltransferase (<i>TMPT</i>) and nucleoside diphosphate-linked moiety X-type motif 15 (&l...

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Bibliographic Details
Main Authors: Krzysztof Wroński, Michał Tadeusz Holecki, Natalia Boguszewska, Marzena Skrzypczak-Zielińska, Jerzy Tadeusz Chudek
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Clinics and Practice
Subjects:
nucleoside diphosphate-linked moiety X-type motif 15
thiopurine methyltransferase
mesalazine
azathioprine
bone marrow aplasia
neutropenic fever
Online Access:https://www.mdpi.com/2039-7283/15/6/114
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