Selective and genetic constraints on pneumococcal serotype switching.

Selective and genetic constraints on pneumococcal serotype switching.

Streptococcus pneumoniae isolates typically express one of over 90 immunologically distinguishable polysaccharide capsules (serotypes), which can be classified into "serogroups" based on cross-reactivity with certain antibodies. Pneumococci can alter their serotype through recombinations a...

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Bibliographic Details
Main Authors: Nicholas J Croucher, Lisa Kagedan, Claudette M Thompson, Julian Parkhill, Stephen D Bentley, Jonathan A Finkelstein, Marc Lipsitch, William P Hanage
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1005095
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