Association of sleep behaviour and pattern with the risk of glaucoma: a prospective cohort study in the UK Biobank
Objectives Given the role of intraocular pressure in glaucoma, the patient’s sleeping pattern might contribute to the development and progression of glaucoma. We performed a study to understand the association between sleep behaviours and glaucoma.Design Our study was a prospective cohort study.Sett...
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| Format: | Article |
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BMJ Publishing Group
2022-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/11/e063676.full |
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| author | Huan Song Huazhen Yang Yao Hu Yajing Sun Zhiye Ying Yuanyuan Qu Cun Sun Yihan Hu |
| author_facet | Huan Song Huazhen Yang Yao Hu Yajing Sun Zhiye Ying Yuanyuan Qu Cun Sun Yihan Hu |
| author_sort | Huan Song |
| collection | DOAJ |
| description | Objectives Given the role of intraocular pressure in glaucoma, the patient’s sleeping pattern might contribute to the development and progression of glaucoma. We performed a study to understand the association between sleep behaviours and glaucoma.Design Our study was a prospective cohort study.Setting This was a prospective cohort study in the UK Biobank. Self-reported data on five sleep behaviours were collected using a questionnaire at baseline. We identified four sleep patterns based on a cluster analysis of the sleep behaviours.Participants In the UK Biobank, 409 053 participants were recruited between 2006 and 2010 and followed for a diagnosis of glaucoma. We identified glaucoma as any hospital admission with a diagnosis of glaucoma, based on UK Biobank inpatient hospital data. Individuals who withdrew from the UK Biobank, or were diagnosed with glaucoma before recruitment, or had self-reported surgery or laser treatment for glaucoma, or had no information on sleep behaviors were excluded.Primary and secondary outcome measures We estimated hazard ratios (HRs) with 95% confidence intervals (CI) using Cox proportional hazards models to estimate the associations of different sleep behaviors, as well as identified sleep patterns, with the risk of glaucoma, adjusting for multiple confounders.Results Compared with individuals who had a healthy sleep pattern, an excess risk of any glaucoma was observed among individuals with snoring and daytime sleepiness (HR 1.11, 95% CI 1.03 to 1.19) or insomnia and short/long sleep duration (HR 1.13, 95% CI 1.06 to 1.20), but not late chronotype sleep pattern (HR 0.98, 95% CI 0.93 to 1.03).Conclusion Snoring, daytime sleepiness, insomnia, and short/long duration, individually or jointly, were all associated with the risk of glaucoma. These findings underscore the need for sleep intervention for individuals at high risk of glaucoma as well as potential ophthalmologic screening among individuals with chronic sleep problems for glaucoma prevention. |
| format | Article |
| id | doaj-art-134e1e5d558f443a94ac5f3ea55b246a |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-134e1e5d558f443a94ac5f3ea55b246a2025-08-20T01:48:12ZengBMJ Publishing GroupBMJ Open2044-60552022-11-01121110.1136/bmjopen-2022-063676Association of sleep behaviour and pattern with the risk of glaucoma: a prospective cohort study in the UK BiobankHuan Song0Huazhen Yang1Yao Hu2Yajing Sun3Zhiye Ying4Yuanyuan Qu5Cun Sun6Yihan Hu73 Med-X Center for Informatics, Sichuan University, Chengdu, ChinaWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USAWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China1 Beijing Huimin Hospital, Beijing, China4 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenObjectives Given the role of intraocular pressure in glaucoma, the patient’s sleeping pattern might contribute to the development and progression of glaucoma. We performed a study to understand the association between sleep behaviours and glaucoma.Design Our study was a prospective cohort study.Setting This was a prospective cohort study in the UK Biobank. Self-reported data on five sleep behaviours were collected using a questionnaire at baseline. We identified four sleep patterns based on a cluster analysis of the sleep behaviours.Participants In the UK Biobank, 409 053 participants were recruited between 2006 and 2010 and followed for a diagnosis of glaucoma. We identified glaucoma as any hospital admission with a diagnosis of glaucoma, based on UK Biobank inpatient hospital data. Individuals who withdrew from the UK Biobank, or were diagnosed with glaucoma before recruitment, or had self-reported surgery or laser treatment for glaucoma, or had no information on sleep behaviors were excluded.Primary and secondary outcome measures We estimated hazard ratios (HRs) with 95% confidence intervals (CI) using Cox proportional hazards models to estimate the associations of different sleep behaviors, as well as identified sleep patterns, with the risk of glaucoma, adjusting for multiple confounders.Results Compared with individuals who had a healthy sleep pattern, an excess risk of any glaucoma was observed among individuals with snoring and daytime sleepiness (HR 1.11, 95% CI 1.03 to 1.19) or insomnia and short/long sleep duration (HR 1.13, 95% CI 1.06 to 1.20), but not late chronotype sleep pattern (HR 0.98, 95% CI 0.93 to 1.03).Conclusion Snoring, daytime sleepiness, insomnia, and short/long duration, individually or jointly, were all associated with the risk of glaucoma. These findings underscore the need for sleep intervention for individuals at high risk of glaucoma as well as potential ophthalmologic screening among individuals with chronic sleep problems for glaucoma prevention.https://bmjopen.bmj.com/content/12/11/e063676.full |
| spellingShingle | Huan Song Huazhen Yang Yao Hu Yajing Sun Zhiye Ying Yuanyuan Qu Cun Sun Yihan Hu Association of sleep behaviour and pattern with the risk of glaucoma: a prospective cohort study in the UK Biobank BMJ Open |
| title | Association of sleep behaviour and pattern with the risk of glaucoma: a prospective cohort study in the UK Biobank |
| title_full | Association of sleep behaviour and pattern with the risk of glaucoma: a prospective cohort study in the UK Biobank |
| title_fullStr | Association of sleep behaviour and pattern with the risk of glaucoma: a prospective cohort study in the UK Biobank |
| title_full_unstemmed | Association of sleep behaviour and pattern with the risk of glaucoma: a prospective cohort study in the UK Biobank |
| title_short | Association of sleep behaviour and pattern with the risk of glaucoma: a prospective cohort study in the UK Biobank |
| title_sort | association of sleep behaviour and pattern with the risk of glaucoma a prospective cohort study in the uk biobank |
| url | https://bmjopen.bmj.com/content/12/11/e063676.full |
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