Unlocking the potential of engineered microbes in immunotoxin-based cancer therapy

Unlocking the potential of engineered microbes in immunotoxin-based cancer therapy

Immunotoxins (ITs), as targeted cancer therapies, confront limitations including off-target effects, immunogenicity, and inadequate tumor penetration, hindering clinical translation. Advances in tumor microenvironment (TME) understanding and genetic engineering have enabled engineered microorganisms...

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Bibliographic Details
Main Authors: Quan Wang, Rui Cao, Yuxing Xie, Zhuoyi Zhang, Xianguo Li, Yan Zhang, Haolin Luo, Hui Yao, Ping Xue, Shuai Ni
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Microbiology
Subjects:
immunotoxin
cancer therapy
engineered microbes
circuits
tumor penetration
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1603671/full
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