Integrated Confocal and Scanning Probe Microscopy for Biomedical Research
Atomic force microscopy (AFM) continues to be developed, not only in design, but also in application. The new focus of using AFM is changing from pure material to biomedical studies. More frequently, it is being used in combination with other optical imaging methods, such as confocal laser scanning...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.269 |
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| _version_ | 1832565763626500096 |
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| author | B.J. Haupt A.E. Pelling M.A. Horton |
| author_facet | B.J. Haupt A.E. Pelling M.A. Horton |
| author_sort | B.J. Haupt |
| collection | DOAJ |
| description | Atomic force microscopy (AFM) continues to be developed, not only in design, but also in application. The new focus of using AFM is changing from pure material to biomedical studies. More frequently, it is being used in combination with other optical imaging methods, such as confocal laser scanning microscopy (CLSM) and fluorescent imaging, to provide a more comprehensive understanding of biological systems. To date, AFM has been used increasingly as a precise micromanipulator, probing and altering the mechanobiological characteristics of living cells and tissues, in order to examine specific, receptor-ligand interactions, material properties, and cell behavior. In this review, we discuss the development of this new hybrid AFM, current research, and potential applications in diagnosis and the detection of disease. |
| format | Article |
| id | doaj-art-1349676cbeef43a4933861f616ddd15d |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1349676cbeef43a4933861f616ddd15d2025-02-03T01:06:45ZengWileyThe Scientific World Journal1537-744X2006-01-0161609161810.1100/tsw.2006.269Integrated Confocal and Scanning Probe Microscopy for Biomedical ResearchB.J. Haupt0A.E. Pelling1M.A. Horton2Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UKRayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UKRayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UKAtomic force microscopy (AFM) continues to be developed, not only in design, but also in application. The new focus of using AFM is changing from pure material to biomedical studies. More frequently, it is being used in combination with other optical imaging methods, such as confocal laser scanning microscopy (CLSM) and fluorescent imaging, to provide a more comprehensive understanding of biological systems. To date, AFM has been used increasingly as a precise micromanipulator, probing and altering the mechanobiological characteristics of living cells and tissues, in order to examine specific, receptor-ligand interactions, material properties, and cell behavior. In this review, we discuss the development of this new hybrid AFM, current research, and potential applications in diagnosis and the detection of disease.http://dx.doi.org/10.1100/tsw.2006.269 |
| spellingShingle | B.J. Haupt A.E. Pelling M.A. Horton Integrated Confocal and Scanning Probe Microscopy for Biomedical Research The Scientific World Journal |
| title | Integrated Confocal and Scanning Probe Microscopy for Biomedical Research |
| title_full | Integrated Confocal and Scanning Probe Microscopy for Biomedical Research |
| title_fullStr | Integrated Confocal and Scanning Probe Microscopy for Biomedical Research |
| title_full_unstemmed | Integrated Confocal and Scanning Probe Microscopy for Biomedical Research |
| title_short | Integrated Confocal and Scanning Probe Microscopy for Biomedical Research |
| title_sort | integrated confocal and scanning probe microscopy for biomedical research |
| url | http://dx.doi.org/10.1100/tsw.2006.269 |
| work_keys_str_mv | AT bjhaupt integratedconfocalandscanningprobemicroscopyforbiomedicalresearch AT aepelling integratedconfocalandscanningprobemicroscopyforbiomedicalresearch AT mahorton integratedconfocalandscanningprobemicroscopyforbiomedicalresearch |