Systematic identification of pathogenic variants of non-small cell lung cancer in the promoters of DNA-damage repair genesResearch in context

Summary: Background: Deficiency in DNA-damage repair (DDR) genes, often due to disruptive coding variants, is linked to higher cancer risk. Our previous study has revealed the association between rare loss-of-function variants in DDR genes and the risk of lung cancer. However, it is still challengi...

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Bibliographic Details
Main Authors:	Mingxing An, Congcong Chen, Jun Xiang, Yang Li, Pinyu Qiu, Yiru Tang, Xinyue Liu, Yayun Gu, Na Qin, Yuanlin He, Meng Zhu, Yue Jiang, Juncheng Dai, Guangfu Jin, Hongxia Ma, Cheng Wang, Zhibin Hu, Hongbing Shen
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Series:	EBioMedicine
Subjects:	DNA-damage repair Non-small cell lung cancer Massively parallel reporter assay Rare variants
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396424005164
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Systematic identification of pathogenic variants of non-small cell lung cancer in the promoters of DNA-damage repair genesResearch in context

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