Need assessment for HIV drug resistance testing and landscape of current and future technologies in low- and middle-income countries.
Resistance to antiretroviral drugs used to treat HIV is an important and evolving concern, particularly in low- and middle-income countries (LMICs) which have been impacted to the greatest extent by the HIV pandemic. Efforts to monitor the emergence and transmission of resistance over the past decad...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
|
| Series: | PLOS Global Public Health |
| Online Access: | https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0001948&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849469114391724032 |
|---|---|
| author | Neil Parkin P Richard Harrigan Seth Inzaule Silvia Bertagnolio |
| author_facet | Neil Parkin P Richard Harrigan Seth Inzaule Silvia Bertagnolio |
| author_sort | Neil Parkin |
| collection | DOAJ |
| description | Resistance to antiretroviral drugs used to treat HIV is an important and evolving concern, particularly in low- and middle-income countries (LMICs) which have been impacted to the greatest extent by the HIV pandemic. Efforts to monitor the emergence and transmission of resistance over the past decade have shown that drug resistance-especially to the nucleoside analogue and non-nucleoside reverse transcriptase inhibitors-can (and have) increased to levels that can jeopardize the efficacy of available treatment options at the population level. The global shift to integrase-based regimens as the preferred first-line therapy as well as technological advancements in the methods for detecting resistance have had an impact in broadening and diversifying the landscape of and use case for HIV drug resistance testing. This review estimates the potential demand for HIV drug resistance tests, and surveys current testing methodologies, with a focus on their application in LMICs. |
| format | Article |
| id | doaj-art-133e468404e248cca7c5921d8be34cbc |
| institution | Kabale University |
| issn | 2767-3375 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Global Public Health |
| spelling | doaj-art-133e468404e248cca7c5921d8be34cbc2025-08-20T03:25:38ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752023-01-01310e000194810.1371/journal.pgph.0001948Need assessment for HIV drug resistance testing and landscape of current and future technologies in low- and middle-income countries.Neil ParkinP Richard HarriganSeth InzauleSilvia BertagnolioResistance to antiretroviral drugs used to treat HIV is an important and evolving concern, particularly in low- and middle-income countries (LMICs) which have been impacted to the greatest extent by the HIV pandemic. Efforts to monitor the emergence and transmission of resistance over the past decade have shown that drug resistance-especially to the nucleoside analogue and non-nucleoside reverse transcriptase inhibitors-can (and have) increased to levels that can jeopardize the efficacy of available treatment options at the population level. The global shift to integrase-based regimens as the preferred first-line therapy as well as technological advancements in the methods for detecting resistance have had an impact in broadening and diversifying the landscape of and use case for HIV drug resistance testing. This review estimates the potential demand for HIV drug resistance tests, and surveys current testing methodologies, with a focus on their application in LMICs.https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0001948&type=printable |
| spellingShingle | Neil Parkin P Richard Harrigan Seth Inzaule Silvia Bertagnolio Need assessment for HIV drug resistance testing and landscape of current and future technologies in low- and middle-income countries. PLOS Global Public Health |
| title | Need assessment for HIV drug resistance testing and landscape of current and future technologies in low- and middle-income countries. |
| title_full | Need assessment for HIV drug resistance testing and landscape of current and future technologies in low- and middle-income countries. |
| title_fullStr | Need assessment for HIV drug resistance testing and landscape of current and future technologies in low- and middle-income countries. |
| title_full_unstemmed | Need assessment for HIV drug resistance testing and landscape of current and future technologies in low- and middle-income countries. |
| title_short | Need assessment for HIV drug resistance testing and landscape of current and future technologies in low- and middle-income countries. |
| title_sort | need assessment for hiv drug resistance testing and landscape of current and future technologies in low and middle income countries |
| url | https://journals.plos.org/globalpublichealth/article/file?id=10.1371/journal.pgph.0001948&type=printable |
| work_keys_str_mv | AT neilparkin needassessmentforhivdrugresistancetestingandlandscapeofcurrentandfuturetechnologiesinlowandmiddleincomecountries AT prichardharrigan needassessmentforhivdrugresistancetestingandlandscapeofcurrentandfuturetechnologiesinlowandmiddleincomecountries AT sethinzaule needassessmentforhivdrugresistancetestingandlandscapeofcurrentandfuturetechnologiesinlowandmiddleincomecountries AT silviabertagnolio needassessmentforhivdrugresistancetestingandlandscapeofcurrentandfuturetechnologiesinlowandmiddleincomecountries |