Role of Radiotherapy in Metastatic Renal Cell Carcinomas: An Evolutionary Journey in a Misunderstood Histological Type
Renal cell carcinoma (RCC) has traditionally been considered one of the most radioresistant tumors based on in vitro and clinical studies that utilized a low biologically effective dose. However, recent studies have suggested that administering a higher radiation dose to RCC can lead to satisfactory...
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| Format: | Article |
| Language: | English |
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Korean Urological Oncology Society
2023-11-01
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| Series: | Journal of Urologic Oncology |
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| Online Access: | http://www.e-juo.org/upload/pdf/juo-21-3-217.pdf |
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| _version_ | 1850057131987828736 |
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| author | Chan Woo Wee Jaeho Cho |
| author_facet | Chan Woo Wee Jaeho Cho |
| author_sort | Chan Woo Wee |
| collection | DOAJ |
| description | Renal cell carcinoma (RCC) has traditionally been considered one of the most radioresistant tumors based on in vitro and clinical studies that utilized a low biologically effective dose. However, recent studies have suggested that administering a higher radiation dose to RCC can lead to satisfactory local control and potentially long-lasting disease control. Thanks to significant advances in radiotherapy technology, it is now feasible to deliver higher radiation doses to tumors while preserving the organs at risk. Furthermore, over the past decade, a crucial role of radiotherapy has emerged in metastatic cancers, both for symptom palliation and for the elimination of tumor niches. This review discusses the current evidence and future perspectives concerning the role of radiotherapy in metastatic RCC. |
| format | Article |
| id | doaj-art-132aa5f50e964f558163c2d327bf5ee2 |
| institution | DOAJ |
| issn | 2951-603X 2982-7043 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Korean Urological Oncology Society |
| record_format | Article |
| series | Journal of Urologic Oncology |
| spelling | doaj-art-132aa5f50e964f558163c2d327bf5ee22025-08-20T02:51:31ZengKorean Urological Oncology SocietyJournal of Urologic Oncology2951-603X2982-70432023-11-0121321722710.22465/juo.234600560028556Role of Radiotherapy in Metastatic Renal Cell Carcinomas: An Evolutionary Journey in a Misunderstood Histological TypeChan Woo Wee0Jaeho Cho1 Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Seoul, Korea Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Seoul, KoreaRenal cell carcinoma (RCC) has traditionally been considered one of the most radioresistant tumors based on in vitro and clinical studies that utilized a low biologically effective dose. However, recent studies have suggested that administering a higher radiation dose to RCC can lead to satisfactory local control and potentially long-lasting disease control. Thanks to significant advances in radiotherapy technology, it is now feasible to deliver higher radiation doses to tumors while preserving the organs at risk. Furthermore, over the past decade, a crucial role of radiotherapy has emerged in metastatic cancers, both for symptom palliation and for the elimination of tumor niches. This review discusses the current evidence and future perspectives concerning the role of radiotherapy in metastatic RCC.http://www.e-juo.org/upload/pdf/juo-21-3-217.pdfrenal cell carcinomaradiotherapyradiation therapysabroligometastasis |
| spellingShingle | Chan Woo Wee Jaeho Cho Role of Radiotherapy in Metastatic Renal Cell Carcinomas: An Evolutionary Journey in a Misunderstood Histological Type Journal of Urologic Oncology renal cell carcinoma radiotherapy radiation therapy sabr oligometastasis |
| title | Role of Radiotherapy in Metastatic Renal Cell Carcinomas: An Evolutionary Journey in a Misunderstood Histological Type |
| title_full | Role of Radiotherapy in Metastatic Renal Cell Carcinomas: An Evolutionary Journey in a Misunderstood Histological Type |
| title_fullStr | Role of Radiotherapy in Metastatic Renal Cell Carcinomas: An Evolutionary Journey in a Misunderstood Histological Type |
| title_full_unstemmed | Role of Radiotherapy in Metastatic Renal Cell Carcinomas: An Evolutionary Journey in a Misunderstood Histological Type |
| title_short | Role of Radiotherapy in Metastatic Renal Cell Carcinomas: An Evolutionary Journey in a Misunderstood Histological Type |
| title_sort | role of radiotherapy in metastatic renal cell carcinomas an evolutionary journey in a misunderstood histological type |
| topic | renal cell carcinoma radiotherapy radiation therapy sabr oligometastasis |
| url | http://www.e-juo.org/upload/pdf/juo-21-3-217.pdf |
| work_keys_str_mv | AT chanwoowee roleofradiotherapyinmetastaticrenalcellcarcinomasanevolutionaryjourneyinamisunderstoodhistologicaltype AT jaehocho roleofradiotherapyinmetastaticrenalcellcarcinomasanevolutionaryjourneyinamisunderstoodhistologicaltype |