Role of tertiary lymphoid structures and B cells in clinical immunotherapy of gastric cancer
Gastric cancer is a common malignant tumor of the digestive tract, and its treatment remains a significant challenge. In recent years, the role of various immune cells in the tumor microenvironment in cancer progression and treatment has gained increasing attention. Immunotherapy, primarily based on...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519034/full |
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| author | Weiyi Chen Lingli Zhang Man Gao Ning Zhang Rumeng Wang Yang Liu Yan Niu Lizhou Jia Lizhou Jia |
| author_facet | Weiyi Chen Lingli Zhang Man Gao Ning Zhang Rumeng Wang Yang Liu Yan Niu Lizhou Jia Lizhou Jia |
| author_sort | Weiyi Chen |
| collection | DOAJ |
| description | Gastric cancer is a common malignant tumor of the digestive tract, and its treatment remains a significant challenge. In recent years, the role of various immune cells in the tumor microenvironment in cancer progression and treatment has gained increasing attention. Immunotherapy, primarily based on immune checkpoint inhibitors, has notably improved the prognosis of patients with gastric cancer; however, challenges regarding therapeutic efficacy persist. Histological features within the tumor microenvironment, such as tertiary lymphoid structures (TLSs), tumor-infiltrating lymphocytes, and the proportion of intratumoral stroma, are emerging as potentially effective prognostic factors. In gastric cancer, TLSs may serve as local immune hubs, enhancing the ability of immune cells to interact with and recognize tumor antigens, which is closely linked to the effectiveness of immunotherapy and improved survival rates in patients. However, the specific cell type driving TLS formation in tumors has not yet been elucidated. Mature TLSs are B-cell regions containing germinal centers. During germinal center formation, B cells undergo transformations to become mature cells with immune function, exerting anti-tumor effects. Therefore, targeting B cells within TLSs could provide new avenues for gastric cancer immunotherapy. This review, combined with current research on TLSs and B cells in gastric cancer, elaborates on the relationship between TLSs and B cells in the prognosis and immunotherapy of patients with gastric cancer, aiming to provide effective guidance for precise immunotherapy. |
| format | Article |
| id | doaj-art-1326bb98e8e4441fae26445513252ba3 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-1326bb98e8e4441fae26445513252ba32025-01-07T06:51:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15190341519034Role of tertiary lymphoid structures and B cells in clinical immunotherapy of gastric cancerWeiyi Chen0Lingli Zhang1Man Gao2Ning Zhang3Rumeng Wang4Yang Liu5Yan Niu6Lizhou Jia7Lizhou Jia8Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, Inner Mongolia, ChinaCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaBayannur Clinical Medical College, Inner Mongolia Medical University, Hohhot, Inner Mongolia, ChinaCentral Laboratory, Bayannur Hospital, Bayannur, Inner Mongolia, ChinaCentral Laboratory, Bayannur Hospital, Bayannur, Inner Mongolia, ChinaCentral Laboratory, Bayannur Hospital, Bayannur, Inner Mongolia, ChinaMedical Experiment Center, Inner Mongolia Medical University, Hohhot, Inner Mongolia, ChinaCentral Laboratory, Bayannur Hospital, Bayannur, Inner Mongolia, ChinaMedical Experiment Center, Inner Mongolia Medical University, Hohhot, Inner Mongolia, ChinaGastric cancer is a common malignant tumor of the digestive tract, and its treatment remains a significant challenge. In recent years, the role of various immune cells in the tumor microenvironment in cancer progression and treatment has gained increasing attention. Immunotherapy, primarily based on immune checkpoint inhibitors, has notably improved the prognosis of patients with gastric cancer; however, challenges regarding therapeutic efficacy persist. Histological features within the tumor microenvironment, such as tertiary lymphoid structures (TLSs), tumor-infiltrating lymphocytes, and the proportion of intratumoral stroma, are emerging as potentially effective prognostic factors. In gastric cancer, TLSs may serve as local immune hubs, enhancing the ability of immune cells to interact with and recognize tumor antigens, which is closely linked to the effectiveness of immunotherapy and improved survival rates in patients. However, the specific cell type driving TLS formation in tumors has not yet been elucidated. Mature TLSs are B-cell regions containing germinal centers. During germinal center formation, B cells undergo transformations to become mature cells with immune function, exerting anti-tumor effects. Therefore, targeting B cells within TLSs could provide new avenues for gastric cancer immunotherapy. This review, combined with current research on TLSs and B cells in gastric cancer, elaborates on the relationship between TLSs and B cells in the prognosis and immunotherapy of patients with gastric cancer, aiming to provide effective guidance for precise immunotherapy.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519034/fullgastric cancertertiary lymphoid structureB cellsimmunotherapyclinical application |
| spellingShingle | Weiyi Chen Lingli Zhang Man Gao Ning Zhang Rumeng Wang Yang Liu Yan Niu Lizhou Jia Lizhou Jia Role of tertiary lymphoid structures and B cells in clinical immunotherapy of gastric cancer Frontiers in Immunology gastric cancer tertiary lymphoid structure B cells immunotherapy clinical application |
| title | Role of tertiary lymphoid structures and B cells in clinical immunotherapy of gastric cancer |
| title_full | Role of tertiary lymphoid structures and B cells in clinical immunotherapy of gastric cancer |
| title_fullStr | Role of tertiary lymphoid structures and B cells in clinical immunotherapy of gastric cancer |
| title_full_unstemmed | Role of tertiary lymphoid structures and B cells in clinical immunotherapy of gastric cancer |
| title_short | Role of tertiary lymphoid structures and B cells in clinical immunotherapy of gastric cancer |
| title_sort | role of tertiary lymphoid structures and b cells in clinical immunotherapy of gastric cancer |
| topic | gastric cancer tertiary lymphoid structure B cells immunotherapy clinical application |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519034/full |
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