Cancer-associated fibroblasts promote drug resistance in ALK-driven lung adenocarcinoma cells by upregulating lipid biosynthesis

Cancer-associated fibroblasts promote drug resistance in ALK-driven lung adenocarcinoma cells by upregulating lipid biosynthesis

Abstract Background Targeted therapy interventions using tyrosine kinase inhibitors (TKIs) provide encouraging treatment responses in patients with ALK-rearranged lung adenocarcinomas, yet resistance occurs almost inevitably. In addition to tumor cell-intrinsic resistance mechanisms, accumulating ev...

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Bibliographic Details
Main Authors: Ann-Kathrin Daum, Lisa Schlicker, Marc A. Schneider, Thomas Muley, Ursula Klingmüller, Almut Schulze, Michael Thomas, Petros Christopoulos, Holger Sültmann
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cancer & Metabolism
Subjects:
Lung adenocarcinoma
EML4-ALK
Cancer-associated fibroblasts
Therapy resistance
Lipid metabolism
3D cell culture
Online Access:https://doi.org/10.1186/s40170-025-00400-7
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