Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis
Purpose. To report favorable outcome of a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) associated with cerebral vasculitis after treatment with immunosuppressive therapy by mitoxantrone. Design. Single case report. Method. A 22-year-old man presented with acute isolated...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2009/481512 |
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| author | Hélène Massé Jean-Laurent Guyomard Dominique Baudet Jean-François Pinel Gilles Edan Jean-François Charlin |
| author_facet | Hélène Massé Jean-Laurent Guyomard Dominique Baudet Jean-François Pinel Gilles Edan Jean-François Charlin |
| author_sort | Hélène Massé |
| collection | DOAJ |
| description | Purpose. To report favorable outcome of a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) associated with cerebral vasculitis after treatment with immunosuppressive therapy by mitoxantrone. Design. Single case report. Method. A 22-year-old man presented with acute isolated bilateral loss of vision revealing APMPPE. Corticosteroid therapy was initiated and visual acuity gradually improved. Seventeen days later, visual function deteriorated again, associated with flu-like syndrome and severe headaches. A relapse of APMPPE was diagnosed, complicated with lymphocytic meningitis and cerebral ischemia. Intravenous therapy with mitoxantrone was performed in combination with methylprednisolone. Results. Headaches disappeared in a few days whereas visual acuity gradually improved and stabilized at 20/40 in the right eye and 20/32 in the left eye. No adverse event was observed. Clinical improvement was confirmed by magnetic resonance imaging. Conclusion. Cerebral vasculitis is the most severe complication of the extraocular manifestations of APMPEE. This diagnosis should be evoked when severe headaches or behavior disorder are associated with APMPEE. |
| format | Article |
| id | doaj-art-1321e1126be04375a1fa3f7dfb52fd83 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
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| series | Case Reports in Medicine |
| spelling | doaj-art-1321e1126be04375a1fa3f7dfb52fd832025-02-03T01:32:03ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/481512481512Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral VasculitisHélène Massé0Jean-Laurent Guyomard1Dominique Baudet2Jean-François Pinel3Gilles Edan4Jean-François Charlin5Service d'ophtalmologie, CHU Pontchaillou, rue Henri Le Guilloux, 35000 Rennes, FranceService d'ophtalmologie, CHU Pontchaillou, rue Henri Le Guilloux, 35000 Rennes, FranceService d'ophtalmologie, CHU Pontchaillou, rue Henri Le Guilloux, 35000 Rennes, FranceService de neurologie, CHU Pontchaillou, rue Henri Le Guilloux, 35000 Rennes, FranceService de neurologie, CHU Pontchaillou, rue Henri Le Guilloux, 35000 Rennes, FranceService d'ophtalmologie, CHU Pontchaillou, rue Henri Le Guilloux, 35000 Rennes, FrancePurpose. To report favorable outcome of a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) associated with cerebral vasculitis after treatment with immunosuppressive therapy by mitoxantrone. Design. Single case report. Method. A 22-year-old man presented with acute isolated bilateral loss of vision revealing APMPPE. Corticosteroid therapy was initiated and visual acuity gradually improved. Seventeen days later, visual function deteriorated again, associated with flu-like syndrome and severe headaches. A relapse of APMPPE was diagnosed, complicated with lymphocytic meningitis and cerebral ischemia. Intravenous therapy with mitoxantrone was performed in combination with methylprednisolone. Results. Headaches disappeared in a few days whereas visual acuity gradually improved and stabilized at 20/40 in the right eye and 20/32 in the left eye. No adverse event was observed. Clinical improvement was confirmed by magnetic resonance imaging. Conclusion. Cerebral vasculitis is the most severe complication of the extraocular manifestations of APMPEE. This diagnosis should be evoked when severe headaches or behavior disorder are associated with APMPEE.http://dx.doi.org/10.1155/2009/481512 |
| spellingShingle | Hélène Massé Jean-Laurent Guyomard Dominique Baudet Jean-François Pinel Gilles Edan Jean-François Charlin Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis Case Reports in Medicine |
| title | Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis |
| title_full | Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis |
| title_fullStr | Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis |
| title_full_unstemmed | Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis |
| title_short | Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis |
| title_sort | mitoxantrone therapy for acute posterior multifocal placoid pigment epitheliopathy with cerebral vasculitis |
| url | http://dx.doi.org/10.1155/2009/481512 |
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