The problem of resistant Trichomonas vaginalis to antiprotozoal drugs
This review presents recent data on the energy metabolism of Trichomonas vaginalis and ways the activation of metronidazole. The sensitivity of microorganisms to the 5-nitroimidazole by the presence of their enzyme systems, generating and transporting electrons, which can then transfer them to the n...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/58 |
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| author | A. L. Poznyak S. S. Kozlov R. V. Gudkov Yu. F. Zaharkiv S. N. Sidorchuk O. L. Molchanov |
| author_facet | A. L. Poznyak S. S. Kozlov R. V. Gudkov Yu. F. Zaharkiv S. N. Sidorchuk O. L. Molchanov |
| author_sort | A. L. Poznyak |
| collection | DOAJ |
| description | This review presents recent data on the energy metabolism of Trichomonas vaginalis and ways the activation of metronidazole. The sensitivity of microorganisms to the 5-nitroimidazole by the presence of their enzyme systems, generating and transporting electrons, which can then transfer them to the nitro group of the drug. In T.vaginalis these are pyruvate ferredoxin-oxydoreductase, thioredoxin reductase and flavin reductase. The development of resistance T.vaginalis to metronidazole preparations of this multistep process, based on the gradual reduction (up to a loss) activity hydrogenosomal enzymes and / or violation of the flavindependent metabolic pathways. |
| format | Article |
| id | doaj-art-1317cf1bf85348e79d5cdcda1c626e55 |
| institution | DOAJ |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-1317cf1bf85348e79d5cdcda1c626e552025-08-20T02:55:16ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-0134344310.22625/2072-6732-2011-3-4-34-4372The problem of resistant Trichomonas vaginalis to antiprotozoal drugsA. L. Poznyak0S. S. Kozlov1R. V. Gudkov2Yu. F. Zaharkiv3S. N. Sidorchuk4O. L. Molchanov5St-Petersburg Medical Academy of Postgradu ate Studies, Saint-PetersburgMilitary Medical Academy by S.М. Kirov, Saint-PetersburgMilitary Medical Academy by S.М. Kirov, Saint-PetersburgMilitary Medical Academy by S.М. Kirov, Saint-PetersburgMilitary Medical Academy by S.М. Kirov, Saint-PetersburgMilitary Medical Academy by S.М. Kirov, Saint-PetersburgThis review presents recent data on the energy metabolism of Trichomonas vaginalis and ways the activation of metronidazole. The sensitivity of microorganisms to the 5-nitroimidazole by the presence of their enzyme systems, generating and transporting electrons, which can then transfer them to the nitro group of the drug. In T.vaginalis these are pyruvate ferredoxin-oxydoreductase, thioredoxin reductase and flavin reductase. The development of resistance T.vaginalis to metronidazole preparations of this multistep process, based on the gradual reduction (up to a loss) activity hydrogenosomal enzymes and / or violation of the flavindependent metabolic pathways.https://journal.niidi.ru/jofin/article/view/58trichomonas vaginalisresistancehydrogenosomesmetronidazole |
| spellingShingle | A. L. Poznyak S. S. Kozlov R. V. Gudkov Yu. F. Zaharkiv S. N. Sidorchuk O. L. Molchanov The problem of resistant Trichomonas vaginalis to antiprotozoal drugs Журнал инфектологии trichomonas vaginalis resistance hydrogenosomes metronidazole |
| title | The problem of resistant Trichomonas vaginalis to antiprotozoal drugs |
| title_full | The problem of resistant Trichomonas vaginalis to antiprotozoal drugs |
| title_fullStr | The problem of resistant Trichomonas vaginalis to antiprotozoal drugs |
| title_full_unstemmed | The problem of resistant Trichomonas vaginalis to antiprotozoal drugs |
| title_short | The problem of resistant Trichomonas vaginalis to antiprotozoal drugs |
| title_sort | problem of resistant trichomonas vaginalis to antiprotozoal drugs |
| topic | trichomonas vaginalis resistance hydrogenosomes metronidazole |
| url | https://journal.niidi.ru/jofin/article/view/58 |
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