MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis

MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis

Abstract This study explores the epigenetic mechanism of MLL1 regulating trophoblast ferroptosis in preeclampsia (PE). A murine model of PE was established, and HTR-8/SVneo cells were induced by Erastin to establish an in vitro cell model. GSH, MDA, Fe2+, and ROS levels were measured to assess ferro...

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Bibliographic Details
Main Authors: Lingling Li, Haining He, Zhenrong Zheng, Xiaolan Zhao
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Biology Direct
Subjects:
Ferroptosis
MLL1
Preeclampsia
RBM15
TRIM72
Online Access:https://doi.org/10.1186/s13062-024-00572-0
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