Assessment of Probability of Pulmonary Fibrosis Progression in Patients with Interstitial Lung Diseases to Determine Further Treatment Tactics
The objective: to develop a method for assessing the probability of progression of pulmonary fibrosis in patients with interstitial lung diseases in order to determine further treatment tactics.Subjects and Methods. 80 patients with interstitial lung diseases underwent lung biopsies with consequent...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2024-07-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1813 |
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| author | A. A. Lukashevich O. A. Yudina L. S. Bogush E. I. Davidovskaya M. I. Dyusmikeeva A. F. Belko |
| author_facet | A. A. Lukashevich O. A. Yudina L. S. Bogush E. I. Davidovskaya M. I. Dyusmikeeva A. F. Belko |
| author_sort | A. A. Lukashevich |
| collection | DOAJ |
| description | The objective: to develop a method for assessing the probability of progression of pulmonary fibrosis in patients with interstitial lung diseases in order to determine further treatment tactics.Subjects and Methods. 80 patients with interstitial lung diseases underwent lung biopsies with consequent morphological and immunohistochemical tests. The group with progressive fibrosis consisted of 42 patients. The prognostic model was built using the binary logistic regression method.Results. A statistical model was developed in the form of a regression equation consisting of 3 parameters: the presence of a morphological pattern of interstitial fibrosis; intensity of CTGF expression; and intensity of TGF-β expression. This mathematical model makes it possible to predict the progression of pulmonary fibrosis in patients with interstitial lung diseases with 83.3% sensitivity and 84.2% specificity. |
| format | Article |
| id | doaj-art-13128aa44ba34bc18a808f00643e1827 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2024-07-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-13128aa44ba34bc18a808f00643e18272025-08-20T01:47:42ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062024-07-011023344010.58838/2075-1230-2024-102-3-34-401808Assessment of Probability of Pulmonary Fibrosis Progression in Patients with Interstitial Lung Diseases to Determine Further Treatment TacticsA. A. Lukashevich0O. A. Yudina1L. S. Bogush2E. I. Davidovskaya3M. I. Dyusmikeeva4A. F. Belko5Belarusian State Medical UniversityRepublican Clinical Medical Center Administration of President of BelarusRepublican Scientific and Practical Center of Pulmonology and PhthisiologyRepublican Scientific and Practical Center of Pulmonology and PhthisiologyRepublican Scientific and Practical Center of Pulmonology and PhthisiologyRepublican Scientific and Practical Center of Pulmonology and PhthisiologyThe objective: to develop a method for assessing the probability of progression of pulmonary fibrosis in patients with interstitial lung diseases in order to determine further treatment tactics.Subjects and Methods. 80 patients with interstitial lung diseases underwent lung biopsies with consequent morphological and immunohistochemical tests. The group with progressive fibrosis consisted of 42 patients. The prognostic model was built using the binary logistic regression method.Results. A statistical model was developed in the form of a regression equation consisting of 3 parameters: the presence of a morphological pattern of interstitial fibrosis; intensity of CTGF expression; and intensity of TGF-β expression. This mathematical model makes it possible to predict the progression of pulmonary fibrosis in patients with interstitial lung diseases with 83.3% sensitivity and 84.2% specificity.https://www.tibl-journal.com/jour/article/view/1813interstitial lung diseasesprogression of lung fibrosismorphological testsimmunohistochemical testprobability prediction |
| spellingShingle | A. A. Lukashevich O. A. Yudina L. S. Bogush E. I. Davidovskaya M. I. Dyusmikeeva A. F. Belko Assessment of Probability of Pulmonary Fibrosis Progression in Patients with Interstitial Lung Diseases to Determine Further Treatment Tactics Туберкулез и болезни лёгких interstitial lung diseases progression of lung fibrosis morphological tests immunohistochemical test probability prediction |
| title | Assessment of Probability of Pulmonary Fibrosis Progression in Patients with Interstitial Lung Diseases to Determine Further Treatment Tactics |
| title_full | Assessment of Probability of Pulmonary Fibrosis Progression in Patients with Interstitial Lung Diseases to Determine Further Treatment Tactics |
| title_fullStr | Assessment of Probability of Pulmonary Fibrosis Progression in Patients with Interstitial Lung Diseases to Determine Further Treatment Tactics |
| title_full_unstemmed | Assessment of Probability of Pulmonary Fibrosis Progression in Patients with Interstitial Lung Diseases to Determine Further Treatment Tactics |
| title_short | Assessment of Probability of Pulmonary Fibrosis Progression in Patients with Interstitial Lung Diseases to Determine Further Treatment Tactics |
| title_sort | assessment of probability of pulmonary fibrosis progression in patients with interstitial lung diseases to determine further treatment tactics |
| topic | interstitial lung diseases progression of lung fibrosis morphological tests immunohistochemical test probability prediction |
| url | https://www.tibl-journal.com/jour/article/view/1813 |
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