Low skeletal muscle mass as a proxy marker of sarcopenia is a risk factor for major complications in older patients undergoing curative colon resections for colon cancer
IntroductionVarious reports have confirmed that low skeletal muscle mass, a proxy marker of sarcopenia, can be a risk factor for surgical and oncological outcomes in colon cancer. We aimed to investigate the effects of skeletal muscle mass index (SMMI) on postoperative complications, overall surviva...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1464978/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841553868636291072 |
|---|---|
| author | İsmail Tırnova Maya Gasimova Hatice Akay Çağla Sarıtürk Aslıhan Güven Mert Özlem Yenidünya Feza Yarbuğ Karakayalı |
| author_facet | İsmail Tırnova Maya Gasimova Hatice Akay Çağla Sarıtürk Aslıhan Güven Mert Özlem Yenidünya Feza Yarbuğ Karakayalı |
| author_sort | İsmail Tırnova |
| collection | DOAJ |
| description | IntroductionVarious reports have confirmed that low skeletal muscle mass, a proxy marker of sarcopenia, can be a risk factor for surgical and oncological outcomes in colon cancer. We aimed to investigate the effects of skeletal muscle mass index (SMMI) on postoperative complications, overall survival (OS), and disease-free survival (DFS) in older patients with colon cancer who underwent elective curative colon resections.Materials and methodsPatients over 65 years old with stage I-III colon cancer who underwent elective curative colon resections between January 2015 and December 2023 were included in this single-center retrospective longitudinal study. Demographics, comorbidities, laboratory data, pathological features, malignant lymph node ratio (MLNR), OS, and DFS were recorded. Controlling Nutritional Status (CONUT) Score was used to assess the nutritional status. An axial portal-phase image was obtained at the level of the third lumbar vertebra, and muscle areas were calculated. SMMI was calculated by dividing the muscle area (cm2) by the square of the patient’s height (m2). Low SMMI was defined as SMMI<41 cm2/m2 in women and < 43 cm2/m2 in men with body mass index (BMI) <25 kg/m2, and as SMMI <53 cm2/m2 in patients with a BMI >25 kg/m2. Postoperative complications were classified according to the Clavien-Dindo system. Univariate and multivariate analyses were performed to investigate the factors related to the postoperative complications, OS and DFS.ResultsIn total, 98 cases (mean age 75.2 ± 6.9, 55.1% male) were included in the study. The median follow-up time was 38.3 (0.5–113) months. There were 64 patients (65.3%) in the Low SMMI group and 34 patients (34.7%) in the Normal SMMI group. Logistic regression analysis demonstrated that low SMMI was associated with a higher risk of major complications, with an odds ratio of 5.3 (95% CI, 1.1–20.1; p = 0.037). Cox regression analysis revealed no significant differences in OS and DFS.ConclusionLow SMMI as a proxy marker of sarcopenia was found to be an independent risk factor for postoperative major complications. Additional prospective studies are warranted to obtain more reliable results. |
| format | Article |
| id | doaj-art-13116558029648fa94ed72b13cc97ba0 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-13116558029648fa94ed72b13cc97ba02025-01-09T06:10:16ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14649781464978Low skeletal muscle mass as a proxy marker of sarcopenia is a risk factor for major complications in older patients undergoing curative colon resections for colon cancerİsmail Tırnova0Maya Gasimova1Hatice Akay2Çağla Sarıtürk3Aslıhan Güven Mert4Özlem Yenidünya5Feza Yarbuğ Karakayalı6Department of General Surgery, Baskent University, Istanbul, TürkiyeDepartment of Radiology, Baskent University, Istanbul, TürkiyeDepartment of Radiology, Baskent University, Istanbul, TürkiyeDepartment of Statistics, Baskent University, Istanbul, TürkiyeDepartment of Internal Medicine, Division of Oncology Baskent University, Istanbul, TürkiyeDepartment of Anesthesiology, Baskent University, Istanbul, TürkiyeDepartment of General Surgery, Baskent University, Istanbul, TürkiyeIntroductionVarious reports have confirmed that low skeletal muscle mass, a proxy marker of sarcopenia, can be a risk factor for surgical and oncological outcomes in colon cancer. We aimed to investigate the effects of skeletal muscle mass index (SMMI) on postoperative complications, overall survival (OS), and disease-free survival (DFS) in older patients with colon cancer who underwent elective curative colon resections.Materials and methodsPatients over 65 years old with stage I-III colon cancer who underwent elective curative colon resections between January 2015 and December 2023 were included in this single-center retrospective longitudinal study. Demographics, comorbidities, laboratory data, pathological features, malignant lymph node ratio (MLNR), OS, and DFS were recorded. Controlling Nutritional Status (CONUT) Score was used to assess the nutritional status. An axial portal-phase image was obtained at the level of the third lumbar vertebra, and muscle areas were calculated. SMMI was calculated by dividing the muscle area (cm2) by the square of the patient’s height (m2). Low SMMI was defined as SMMI<41 cm2/m2 in women and < 43 cm2/m2 in men with body mass index (BMI) <25 kg/m2, and as SMMI <53 cm2/m2 in patients with a BMI >25 kg/m2. Postoperative complications were classified according to the Clavien-Dindo system. Univariate and multivariate analyses were performed to investigate the factors related to the postoperative complications, OS and DFS.ResultsIn total, 98 cases (mean age 75.2 ± 6.9, 55.1% male) were included in the study. The median follow-up time was 38.3 (0.5–113) months. There were 64 patients (65.3%) in the Low SMMI group and 34 patients (34.7%) in the Normal SMMI group. Logistic regression analysis demonstrated that low SMMI was associated with a higher risk of major complications, with an odds ratio of 5.3 (95% CI, 1.1–20.1; p = 0.037). Cox regression analysis revealed no significant differences in OS and DFS.ConclusionLow SMMI as a proxy marker of sarcopenia was found to be an independent risk factor for postoperative major complications. Additional prospective studies are warranted to obtain more reliable results.https://www.frontiersin.org/articles/10.3389/fmed.2024.1464978/fullcolon cancersarcopeniaskeletal muscle mass indexgeriatricscomplicationsurvival |
| spellingShingle | İsmail Tırnova Maya Gasimova Hatice Akay Çağla Sarıtürk Aslıhan Güven Mert Özlem Yenidünya Feza Yarbuğ Karakayalı Low skeletal muscle mass as a proxy marker of sarcopenia is a risk factor for major complications in older patients undergoing curative colon resections for colon cancer Frontiers in Medicine colon cancer sarcopenia skeletal muscle mass index geriatrics complication survival |
| title | Low skeletal muscle mass as a proxy marker of sarcopenia is a risk factor for major complications in older patients undergoing curative colon resections for colon cancer |
| title_full | Low skeletal muscle mass as a proxy marker of sarcopenia is a risk factor for major complications in older patients undergoing curative colon resections for colon cancer |
| title_fullStr | Low skeletal muscle mass as a proxy marker of sarcopenia is a risk factor for major complications in older patients undergoing curative colon resections for colon cancer |
| title_full_unstemmed | Low skeletal muscle mass as a proxy marker of sarcopenia is a risk factor for major complications in older patients undergoing curative colon resections for colon cancer |
| title_short | Low skeletal muscle mass as a proxy marker of sarcopenia is a risk factor for major complications in older patients undergoing curative colon resections for colon cancer |
| title_sort | low skeletal muscle mass as a proxy marker of sarcopenia is a risk factor for major complications in older patients undergoing curative colon resections for colon cancer |
| topic | colon cancer sarcopenia skeletal muscle mass index geriatrics complication survival |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1464978/full |
| work_keys_str_mv | AT ismailtırnova lowskeletalmusclemassasaproxymarkerofsarcopeniaisariskfactorformajorcomplicationsinolderpatientsundergoingcurativecolonresectionsforcoloncancer AT mayagasimova lowskeletalmusclemassasaproxymarkerofsarcopeniaisariskfactorformajorcomplicationsinolderpatientsundergoingcurativecolonresectionsforcoloncancer AT haticeakay lowskeletalmusclemassasaproxymarkerofsarcopeniaisariskfactorformajorcomplicationsinolderpatientsundergoingcurativecolonresectionsforcoloncancer AT caglasarıturk lowskeletalmusclemassasaproxymarkerofsarcopeniaisariskfactorformajorcomplicationsinolderpatientsundergoingcurativecolonresectionsforcoloncancer AT aslıhanguvenmert lowskeletalmusclemassasaproxymarkerofsarcopeniaisariskfactorformajorcomplicationsinolderpatientsundergoingcurativecolonresectionsforcoloncancer AT ozlemyenidunya lowskeletalmusclemassasaproxymarkerofsarcopeniaisariskfactorformajorcomplicationsinolderpatientsundergoingcurativecolonresectionsforcoloncancer AT fezayarbugkarakayalı lowskeletalmusclemassasaproxymarkerofsarcopeniaisariskfactorformajorcomplicationsinolderpatientsundergoingcurativecolonresectionsforcoloncancer |