A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13)
Background. We hereby describe what we believe to be the first reported case of t (14; 15) (q32; q13) associated with acute myeloid leukemia (AML). Methods. PubMed, Embase, and OVID search engines were used to review the related literature and similar published cases. Case. A47-year-old female prese...
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Wiley
2014-01-01
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| Series: | Case Reports in Genetics |
| Online Access: | http://dx.doi.org/10.1155/2014/921240 |
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| author | Mohamad Khawandanah Bradley Gehrs Shibo Li Jennifer Holter Chakrabarty Mohamad Cherry |
| author_facet | Mohamad Khawandanah Bradley Gehrs Shibo Li Jennifer Holter Chakrabarty Mohamad Cherry |
| author_sort | Mohamad Khawandanah |
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| description | Background. We hereby describe what we believe to be the first reported case of t (14; 15) (q32; q13) associated with acute myeloid leukemia (AML). Methods. PubMed, Embase, and OVID search engines were used to review the related literature and similar published cases. Case. A47-year-old female presented in December 2011 with AML (acute myelomonocytic leukemia) with normal cytogenetics; molecular testing revealed FLT-3 internal tandem duplication (ITD) mutation, while no mutations involving FLT3 D385/I836, NPM1 exon 12, or KIT exons 8 and 17 were detected. She was induced with 7 + 3 (cytarabine + idarubicin) and achieved complete remission after a second induction with high-dose cytarabine (HiDAC) followed by uneventful consolidation. She presented 19 months after diagnosis with relapsed disease. Of note, at relapse cytogenetic analysis revealed t (14; 15) (q32; q13), while FLT-3 analysis showed a codon D835 mutation (no ITD mutation was detected). She proved refractory to the initial clofarabine-based regimen, so FLAG-idarubicin then was used. She continued to have persistent disease, and she was discharged on best supportive care. Conclusion. Based on this single case of AML with t (14; 15) (q32; q13), this newly reported translocation may be associated with refractory disease. |
| format | Article |
| id | doaj-art-130cd46dea714ee3a582b809c58ef7a8 |
| institution | OA Journals |
| issn | 2090-6544 2090-6552 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | Case Reports in Genetics |
| spelling | doaj-art-130cd46dea714ee3a582b809c58ef7a82025-08-20T02:01:42ZengWileyCase Reports in Genetics2090-65442090-65522014-01-01201410.1155/2014/921240921240A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13)Mohamad Khawandanah0Bradley Gehrs1Shibo Li2Jennifer Holter Chakrabarty3Mohamad Cherry4Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAHematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAHematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USABackground. We hereby describe what we believe to be the first reported case of t (14; 15) (q32; q13) associated with acute myeloid leukemia (AML). Methods. PubMed, Embase, and OVID search engines were used to review the related literature and similar published cases. Case. A47-year-old female presented in December 2011 with AML (acute myelomonocytic leukemia) with normal cytogenetics; molecular testing revealed FLT-3 internal tandem duplication (ITD) mutation, while no mutations involving FLT3 D385/I836, NPM1 exon 12, or KIT exons 8 and 17 were detected. She was induced with 7 + 3 (cytarabine + idarubicin) and achieved complete remission after a second induction with high-dose cytarabine (HiDAC) followed by uneventful consolidation. She presented 19 months after diagnosis with relapsed disease. Of note, at relapse cytogenetic analysis revealed t (14; 15) (q32; q13), while FLT-3 analysis showed a codon D835 mutation (no ITD mutation was detected). She proved refractory to the initial clofarabine-based regimen, so FLAG-idarubicin then was used. She continued to have persistent disease, and she was discharged on best supportive care. Conclusion. Based on this single case of AML with t (14; 15) (q32; q13), this newly reported translocation may be associated with refractory disease.http://dx.doi.org/10.1155/2014/921240 |
| spellingShingle | Mohamad Khawandanah Bradley Gehrs Shibo Li Jennifer Holter Chakrabarty Mohamad Cherry A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13) Case Reports in Genetics |
| title | A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13) |
| title_full | A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13) |
| title_fullStr | A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13) |
| title_full_unstemmed | A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13) |
| title_short | A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15) (q32; q13) |
| title_sort | case of acute myeloid leukemia with a previously unreported translocation 14 15 q32 q13 |
| url | http://dx.doi.org/10.1155/2014/921240 |
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