Optimized Effects of Fisetin and Hydroxychloroquine on ER Stress and Autophagy in Nonalcoholic Fatty Pancreas Disease in Mice
Conclusion: Our study reveals that FSN and HCQ effectively combat HFD-induced NAFPD, improving insulin sensitivity and addressing pancreatic fat deposition linked to metabolic syndrome. While HCQ may cause endoplasmic reticulum stress, FSN offers protective effects, supporting their combined use for...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/jdr/2795127 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849710881203552256 |
|---|---|
| author | Mahboobe Sattari Amin Karimpour Maryam Akhavan Taheri Bagher Larijani Reza Meshkani Ozra Tabatabaei-Malazy Ghodratollah Panahi |
| author_facet | Mahboobe Sattari Amin Karimpour Maryam Akhavan Taheri Bagher Larijani Reza Meshkani Ozra Tabatabaei-Malazy Ghodratollah Panahi |
| author_sort | Mahboobe Sattari |
| collection | DOAJ |
| description | Conclusion: Our study reveals that FSN and HCQ effectively combat HFD-induced NAFPD, improving insulin sensitivity and addressing pancreatic fat deposition linked to metabolic syndrome. While HCQ may cause endoplasmic reticulum stress, FSN offers protective effects, supporting their combined use for better treatment outcomes. |
| format | Article |
| id | doaj-art-130b6bb0d5dd4c3ab074176d8a16002a |
| institution | DOAJ |
| issn | 2314-6753 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-130b6bb0d5dd4c3ab074176d8a16002a2025-08-20T03:14:46ZengWileyJournal of Diabetes Research2314-67532025-01-01202510.1155/jdr/2795127Optimized Effects of Fisetin and Hydroxychloroquine on ER Stress and Autophagy in Nonalcoholic Fatty Pancreas Disease in MiceMahboobe Sattari0Amin Karimpour1Maryam Akhavan Taheri2Bagher Larijani3Reza Meshkani4Ozra Tabatabaei-Malazy5Ghodratollah Panahi6Endocrinology and Metabolism Research CenterDepartment of Clinical BiochemistryAnatomical Sciences Research CenterEndocrinology and Metabolism Research CenterDepartment of Clinical BiochemistryNon-Communicable Diseases Research CenterDepartment of Clinical BiochemistryConclusion: Our study reveals that FSN and HCQ effectively combat HFD-induced NAFPD, improving insulin sensitivity and addressing pancreatic fat deposition linked to metabolic syndrome. While HCQ may cause endoplasmic reticulum stress, FSN offers protective effects, supporting their combined use for better treatment outcomes.http://dx.doi.org/10.1155/jdr/2795127 |
| spellingShingle | Mahboobe Sattari Amin Karimpour Maryam Akhavan Taheri Bagher Larijani Reza Meshkani Ozra Tabatabaei-Malazy Ghodratollah Panahi Optimized Effects of Fisetin and Hydroxychloroquine on ER Stress and Autophagy in Nonalcoholic Fatty Pancreas Disease in Mice Journal of Diabetes Research |
| title | Optimized Effects of Fisetin and Hydroxychloroquine on ER Stress and Autophagy in Nonalcoholic Fatty Pancreas Disease in Mice |
| title_full | Optimized Effects of Fisetin and Hydroxychloroquine on ER Stress and Autophagy in Nonalcoholic Fatty Pancreas Disease in Mice |
| title_fullStr | Optimized Effects of Fisetin and Hydroxychloroquine on ER Stress and Autophagy in Nonalcoholic Fatty Pancreas Disease in Mice |
| title_full_unstemmed | Optimized Effects of Fisetin and Hydroxychloroquine on ER Stress and Autophagy in Nonalcoholic Fatty Pancreas Disease in Mice |
| title_short | Optimized Effects of Fisetin and Hydroxychloroquine on ER Stress and Autophagy in Nonalcoholic Fatty Pancreas Disease in Mice |
| title_sort | optimized effects of fisetin and hydroxychloroquine on er stress and autophagy in nonalcoholic fatty pancreas disease in mice |
| url | http://dx.doi.org/10.1155/jdr/2795127 |
| work_keys_str_mv | AT mahboobesattari optimizedeffectsoffisetinandhydroxychloroquineonerstressandautophagyinnonalcoholicfattypancreasdiseaseinmice AT aminkarimpour optimizedeffectsoffisetinandhydroxychloroquineonerstressandautophagyinnonalcoholicfattypancreasdiseaseinmice AT maryamakhavantaheri optimizedeffectsoffisetinandhydroxychloroquineonerstressandautophagyinnonalcoholicfattypancreasdiseaseinmice AT bagherlarijani optimizedeffectsoffisetinandhydroxychloroquineonerstressandautophagyinnonalcoholicfattypancreasdiseaseinmice AT rezameshkani optimizedeffectsoffisetinandhydroxychloroquineonerstressandautophagyinnonalcoholicfattypancreasdiseaseinmice AT ozratabatabaeimalazy optimizedeffectsoffisetinandhydroxychloroquineonerstressandautophagyinnonalcoholicfattypancreasdiseaseinmice AT ghodratollahpanahi optimizedeffectsoffisetinandhydroxychloroquineonerstressandautophagyinnonalcoholicfattypancreasdiseaseinmice |