Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactants
The aim of the paper was to obtain a stable micellar emulsion of potent photosensitizer (PS) – O-propyloxime-N-propoxybacteriopurpurinimide methyl ester absorbing light in long-wave region of the spectrum (λmax = 800±2 нм). Solubilizates of the dye based on different surfactants (Kolliphor ELP, Polo...
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2019-04-01
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| Series: | Biomedical Photonics |
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| Online Access: | https://www.pdt-journal.com/jour/article/view/289 |
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| author | E. A. Plotnikova V. O. Stramova N. B. Morozova A. D. Plyutinskaya P. V. Ostroverkhov M. A. Grin A. F. Mironov R. I. Yakubovskaya A. D. Kaprin |
| author_facet | E. A. Plotnikova V. O. Stramova N. B. Morozova A. D. Plyutinskaya P. V. Ostroverkhov M. A. Grin A. F. Mironov R. I. Yakubovskaya A. D. Kaprin |
| author_sort | E. A. Plotnikova |
| collection | DOAJ |
| description | The aim of the paper was to obtain a stable micellar emulsion of potent photosensitizer (PS) – O-propyloxime-N-propoxybacteriopurpurinimide methyl ester absorbing light in long-wave region of the spectrum (λmax = 800±2 нм). Solubilizates of the dye based on different surfactants (Kolliphor ELP, Poloxamer 407, Emuxol 268) were obtained. Taking into account the physical and chemical parameters, the most potent micellar emulsion for injection was selected and characterized. The emulsion based on Kolliphor ELP remains stable for 4 months, with no changes in the fluorescence spectrum and absorption, as well as the particle diameter. |
| format | Article |
| id | doaj-art-130a6ac5ee554ae5a2d74b36cf5f618e |
| institution | Kabale University |
| issn | 2413-9432 |
| language | Russian |
| publishDate | 2019-04-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj-art-130a6ac5ee554ae5a2d74b36cf5f618e2025-08-20T03:35:29ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322019-04-0181182310.24931/2413-9432-2019-8-1-18-23157Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactantsE. A. Plotnikova0V. O. Stramova1N. B. Morozova2A. D. Plyutinskaya3P. V. Ostroverkhov4M. A. Grin5A. F. Mironov6R. I. Yakubovskaya7A. D. Kaprin8P.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of Russia, MoscowP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of Russia, MoscowP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of Russia, MoscowP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of Russia, MoscowFederal State Budget Educational Institution of Higher Education “MIREA – Moscow Technological University”, MoscowFederal State Budget Educational Institution of Higher Education “MIREA – Moscow Technological University”, MoscowFederal State Budget Educational Institution of Higher Education “MIREA – Moscow Technological University”, MoscowP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of Russia, MoscowP.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of Russia, MoscowThe aim of the paper was to obtain a stable micellar emulsion of potent photosensitizer (PS) – O-propyloxime-N-propoxybacteriopurpurinimide methyl ester absorbing light in long-wave region of the spectrum (λmax = 800±2 нм). Solubilizates of the dye based on different surfactants (Kolliphor ELP, Poloxamer 407, Emuxol 268) were obtained. Taking into account the physical and chemical parameters, the most potent micellar emulsion for injection was selected and characterized. The emulsion based on Kolliphor ELP remains stable for 4 months, with no changes in the fluorescence spectrum and absorption, as well as the particle diameter.https://www.pdt-journal.com/jour/article/view/289photosensitizerphotodynamic therapybacteriochlorinsolubilizeremulsion |
| spellingShingle | E. A. Plotnikova V. O. Stramova N. B. Morozova A. D. Plyutinskaya P. V. Ostroverkhov M. A. Grin A. F. Mironov R. I. Yakubovskaya A. D. Kaprin Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactants Biomedical Photonics photosensitizer photodynamic therapy bacteriochlorin solubilizer emulsion |
| title | Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactants |
| title_full | Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactants |
| title_fullStr | Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactants |
| title_full_unstemmed | Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactants |
| title_short | Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactants |
| title_sort | solubilization of hydrophobic bacteriochlorin based photosensitizers in micelles of surfactants |
| topic | photosensitizer photodynamic therapy bacteriochlorin solubilizer emulsion |
| url | https://www.pdt-journal.com/jour/article/view/289 |
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