Association between composite dietary antioxidant index and hyperlipidemia in adults based on the NHANES
Abstract Hyperlipidemia, a major risk factor for cardiovascular diseases, can potentially be alleviated by dietary antioxidants. This study explored the relationship between hyperlipidemia and the Composite Dietary Antioxidant Index (CDAI), which measures antioxidant intake from carotenoids, seleniu...
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| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86223-4 |
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| author | Kaidi Nie Tingting Deng Yiling Bai Yuxian Zhang Zhixuan Chen Xile Peng Lina Xia Jiao Liu |
| author_facet | Kaidi Nie Tingting Deng Yiling Bai Yuxian Zhang Zhixuan Chen Xile Peng Lina Xia Jiao Liu |
| author_sort | Kaidi Nie |
| collection | DOAJ |
| description | Abstract Hyperlipidemia, a major risk factor for cardiovascular diseases, can potentially be alleviated by dietary antioxidants. This study explored the relationship between hyperlipidemia and the Composite Dietary Antioxidant Index (CDAI), which measures antioxidant intake from carotenoids, selenium, zinc, and vitamins A, C, and E. Analyzing data from 27,493 participants aged 20 and older from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2018, we used weighted regression models to assess this association while adjusting for multiple covariates. Restricted cubic splines were also applied to check for any non-linear relationships. Findings revealed that higher CDAI scores significantly correlated with lower hyperlipidemia prevalence. Specifically, each unit increase in log-transformed CDAI was linked to a 14% decrease in hyperlipidemia risk (OR = 0.86, 95% CI: 0.77–0.95). Participants in the top CDAI quartile had a 15% lower hyperlipidemia prevalence compared to those in the bottom quartile (OR = 0.85, 95% CI: 0.77–0.95). No significant non-linear relationship was observed (p = 0.822). In conclusion, increased antioxidant intake, as measured by CDAI, is associated with reduced hyperlipidemia, underscoring the role of antioxidants in its management. |
| format | Article |
| id | doaj-art-13040331d4814f6d941c5f9d9a0836d5 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-13040331d4814f6d941c5f9d9a0836d52025-01-19T12:21:42ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-86223-4Association between composite dietary antioxidant index and hyperlipidemia in adults based on the NHANESKaidi Nie0Tingting Deng1Yiling Bai2Yuxian Zhang3Zhixuan Chen4Xile Peng5Lina Xia6Jiao Liu7Key Laboratory of Traditional Chinese Medicine Regimen and Health, State Administration of Traditional Chinese Medicine, Chengdu University of Traditional Chinese MedicineKey Laboratory of Traditional Chinese Medicine Regimen and Health, State Administration of Traditional Chinese Medicine, Chengdu University of Traditional Chinese MedicineKey Laboratory of Traditional Chinese Medicine Regimen and Health, State Administration of Traditional Chinese Medicine, Chengdu University of Traditional Chinese MedicineKey Laboratory of Traditional Chinese Medicine Regimen and Health, State Administration of Traditional Chinese Medicine, Chengdu University of Traditional Chinese MedicineKey Laboratory of Traditional Chinese Medicine Regimen and Health, State Administration of Traditional Chinese Medicine, Chengdu University of Traditional Chinese MedicineKey Laboratory of Traditional Chinese Medicine Regimen and Health, State Administration of Traditional Chinese Medicine, Chengdu University of Traditional Chinese MedicineKey Laboratory of Traditional Chinese Medicine Regimen and Health, State Administration of Traditional Chinese Medicine, Chengdu University of Traditional Chinese MedicineKey Laboratory of Traditional Chinese Medicine Regimen and Health, State Administration of Traditional Chinese Medicine, Chengdu University of Traditional Chinese MedicineAbstract Hyperlipidemia, a major risk factor for cardiovascular diseases, can potentially be alleviated by dietary antioxidants. This study explored the relationship between hyperlipidemia and the Composite Dietary Antioxidant Index (CDAI), which measures antioxidant intake from carotenoids, selenium, zinc, and vitamins A, C, and E. Analyzing data from 27,493 participants aged 20 and older from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2018, we used weighted regression models to assess this association while adjusting for multiple covariates. Restricted cubic splines were also applied to check for any non-linear relationships. Findings revealed that higher CDAI scores significantly correlated with lower hyperlipidemia prevalence. Specifically, each unit increase in log-transformed CDAI was linked to a 14% decrease in hyperlipidemia risk (OR = 0.86, 95% CI: 0.77–0.95). Participants in the top CDAI quartile had a 15% lower hyperlipidemia prevalence compared to those in the bottom quartile (OR = 0.85, 95% CI: 0.77–0.95). No significant non-linear relationship was observed (p = 0.822). In conclusion, increased antioxidant intake, as measured by CDAI, is associated with reduced hyperlipidemia, underscoring the role of antioxidants in its management.https://doi.org/10.1038/s41598-025-86223-4HyperlipidemiaDietary antioxidantsComposite dietary antioxidant index (CDAI)Cross-sectional analysisNHANES |
| spellingShingle | Kaidi Nie Tingting Deng Yiling Bai Yuxian Zhang Zhixuan Chen Xile Peng Lina Xia Jiao Liu Association between composite dietary antioxidant index and hyperlipidemia in adults based on the NHANES Scientific Reports Hyperlipidemia Dietary antioxidants Composite dietary antioxidant index (CDAI) Cross-sectional analysis NHANES |
| title | Association between composite dietary antioxidant index and hyperlipidemia in adults based on the NHANES |
| title_full | Association between composite dietary antioxidant index and hyperlipidemia in adults based on the NHANES |
| title_fullStr | Association between composite dietary antioxidant index and hyperlipidemia in adults based on the NHANES |
| title_full_unstemmed | Association between composite dietary antioxidant index and hyperlipidemia in adults based on the NHANES |
| title_short | Association between composite dietary antioxidant index and hyperlipidemia in adults based on the NHANES |
| title_sort | association between composite dietary antioxidant index and hyperlipidemia in adults based on the nhanes |
| topic | Hyperlipidemia Dietary antioxidants Composite dietary antioxidant index (CDAI) Cross-sectional analysis NHANES |
| url | https://doi.org/10.1038/s41598-025-86223-4 |
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