Phagocytosis‐dependent activation of a TLR9–BTK–calcineurin–NFAT pathway co‐ordinates innate immunity to Aspergillus fumigatus

Phagocytosis‐dependent activation of a TLR9–BTK–calcineurin–NFAT pathway co‐ordinates innate immunity to Aspergillus fumigatus

Abstract Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection. Here, we show that the calcineurin inhibitor tacrolimus impairs clearance of the m...

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Bibliographic Details
Main Authors: Susanne Herbst, Anand Shah, Maria Mazon Moya, Vanessa Marzola, Barbara Jensen, Anna Reed, Mark A Birrell, Shinobu Saijo, Serge Mostowy, Sunil Shaunak, Darius Armstrong‐James
Format: Article
Language:English
Published: Springer Nature 2015-01-01
Series:EMBO Molecular Medicine
Subjects:
aspergillus
calcineurin
phagocytosis
TLR9
transplant
Online Access:https://doi.org/10.15252/emmm.201404556
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