Exploring the active chemical compounds and pharmacological effects of Artemisia Argyi leaves through commonality, authenticity and aging
Background: Artemisia argyi (A. argyi), a pivotal herb extensively used in moxibustion therapy, has long been widely recognized in Traditional Chinese Medicine (TCM) for its significant clinical efficacy. Since the therapeutic effects of a drug are inherently linked to its chemical composition, the...
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Elsevier
2025-11-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266703132500140X |
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| author | Boyu Chen Jiaxin Liu Xu Dai Lufan Xu Wenying Cui Rouan Chen Tian Lan Yiider Tseng |
| author_facet | Boyu Chen Jiaxin Liu Xu Dai Lufan Xu Wenying Cui Rouan Chen Tian Lan Yiider Tseng |
| author_sort | Boyu Chen |
| collection | DOAJ |
| description | Background: Artemisia argyi (A. argyi), a pivotal herb extensively used in moxibustion therapy, has long been widely recognized in Traditional Chinese Medicine (TCM) for its significant clinical efficacy. Since the therapeutic effects of a drug are inherently linked to its chemical composition, the identification of potential active compounds in A. argyi leaves becomes one of the priorities for continuously advancing moxibustion. Purpose: Hence, this study aims to extract key bioactive compounds contributing to its medicinal properties by performing data mining from literature. Three criteria, commonality, authenticity and aging, are applied to identify the common compounds across different regions; the superior compounds unique to the authentic Qichun A. argyi leaves; and the distinctive compounds emerging during the aging process. Methods: Data-driven approaches, which have been developed through decades of literature mining, are grounded in conventional evaluation principles of commonality, authenticity, and aging. The therapeutic effects of bioactive compounds have been verified using 3 individual rheumatoid arthritis (RA)-associated primary fibroblast-like synovial cells (FLS) with 3 times. The anti-proliferative effects were assessed utilizing the CCK-8 assay and the real-time cell analysis (RTCA) system. In addition, the anti-invasive effects were also evaluated through RTCA, while the anti-inflammatory effects were investigated using enzyme-linked immunosorbent assays (ELISA). Results: Our work highlights the potential key functional compounds of A. argyi leaves, including volatile substances, including 1,8-Cineole, β-Caryophyllene, p-Cymene and Caryophyllene oxide, as well as non-volatile compounds, including Eupatilin, Isochlorogenic acid C, Isochlorogenic acid A, and Vitexin. We further validated the anti-proliferative, anti-invasive and anti-inflammatory effects of these compounds on RA-FLS in vitro, demonstrating their therapeutic potential in RA. Conclusion: This approach, established by three criteria, commonality, authenticity and aging, has identify bioactive compounds in A. argyi that may play a therapeutic role by altering the pathologic phenotype of cells. This study provides insights towards pharmacological research of A. argyi and elucidates unknown therapeutic mechanisms against RA. |
| format | Article |
| id | doaj-art-13016db473c2401fb218a7eeaa9da948 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-13016db473c2401fb218a7eeaa9da9482025-08-24T05:14:54ZengElsevierPhytomedicine Plus2667-03132025-11-015410086910.1016/j.phyplu.2025.100869Exploring the active chemical compounds and pharmacological effects of Artemisia Argyi leaves through commonality, authenticity and agingBoyu Chen0Jiaxin Liu1Xu Dai2Lufan Xu3Wenying Cui4Rouan Chen5Tian Lan6Yiider Tseng7College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Acupuncture-Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, ChinaInternational College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan, ChinaInnovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China; Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China; Corresponding author at: Room 217, Innovation Research Building, Room 217; No.4655, Daxue Road, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China; Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China; Corresponding author at: Room 217, Innovation Research Building, Room 217; No.4655, Daxue Road, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.Background: Artemisia argyi (A. argyi), a pivotal herb extensively used in moxibustion therapy, has long been widely recognized in Traditional Chinese Medicine (TCM) for its significant clinical efficacy. Since the therapeutic effects of a drug are inherently linked to its chemical composition, the identification of potential active compounds in A. argyi leaves becomes one of the priorities for continuously advancing moxibustion. Purpose: Hence, this study aims to extract key bioactive compounds contributing to its medicinal properties by performing data mining from literature. Three criteria, commonality, authenticity and aging, are applied to identify the common compounds across different regions; the superior compounds unique to the authentic Qichun A. argyi leaves; and the distinctive compounds emerging during the aging process. Methods: Data-driven approaches, which have been developed through decades of literature mining, are grounded in conventional evaluation principles of commonality, authenticity, and aging. The therapeutic effects of bioactive compounds have been verified using 3 individual rheumatoid arthritis (RA)-associated primary fibroblast-like synovial cells (FLS) with 3 times. The anti-proliferative effects were assessed utilizing the CCK-8 assay and the real-time cell analysis (RTCA) system. In addition, the anti-invasive effects were also evaluated through RTCA, while the anti-inflammatory effects were investigated using enzyme-linked immunosorbent assays (ELISA). Results: Our work highlights the potential key functional compounds of A. argyi leaves, including volatile substances, including 1,8-Cineole, β-Caryophyllene, p-Cymene and Caryophyllene oxide, as well as non-volatile compounds, including Eupatilin, Isochlorogenic acid C, Isochlorogenic acid A, and Vitexin. We further validated the anti-proliferative, anti-invasive and anti-inflammatory effects of these compounds on RA-FLS in vitro, demonstrating their therapeutic potential in RA. Conclusion: This approach, established by three criteria, commonality, authenticity and aging, has identify bioactive compounds in A. argyi that may play a therapeutic role by altering the pathologic phenotype of cells. This study provides insights towards pharmacological research of A. argyi and elucidates unknown therapeutic mechanisms against RA.http://www.sciencedirect.com/science/article/pii/S266703132500140XArtemisia argyiQichun Artemisia leafQi AiAging processAuthenticRheumatoid arthritis |
| spellingShingle | Boyu Chen Jiaxin Liu Xu Dai Lufan Xu Wenying Cui Rouan Chen Tian Lan Yiider Tseng Exploring the active chemical compounds and pharmacological effects of Artemisia Argyi leaves through commonality, authenticity and aging Phytomedicine Plus Artemisia argyi Qichun Artemisia leaf Qi Ai Aging process Authentic Rheumatoid arthritis |
| title | Exploring the active chemical compounds and pharmacological effects of Artemisia Argyi leaves through commonality, authenticity and aging |
| title_full | Exploring the active chemical compounds and pharmacological effects of Artemisia Argyi leaves through commonality, authenticity and aging |
| title_fullStr | Exploring the active chemical compounds and pharmacological effects of Artemisia Argyi leaves through commonality, authenticity and aging |
| title_full_unstemmed | Exploring the active chemical compounds and pharmacological effects of Artemisia Argyi leaves through commonality, authenticity and aging |
| title_short | Exploring the active chemical compounds and pharmacological effects of Artemisia Argyi leaves through commonality, authenticity and aging |
| title_sort | exploring the active chemical compounds and pharmacological effects of artemisia argyi leaves through commonality authenticity and aging |
| topic | Artemisia argyi Qichun Artemisia leaf Qi Ai Aging process Authentic Rheumatoid arthritis |
| url | http://www.sciencedirect.com/science/article/pii/S266703132500140X |
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