Relationship between Wnt/β-catenin signaling pathway and lupus nephritis
Objective To evaluate the Wnt/βcatenin signaling biomarkers in lupus nephritis(LN)patients.Methods Eighteen patients with lupus nephritis in Lanzhou University Second Hospital from2015 to 2016 were included,and 19 healthy people served as normal control group.The expression of Wnt1,β-cateninand DKK1...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Nephrology
2018-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57916166&Fpath=home&index=0 |
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| _version_ | 1849728824972935168 |
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| author | MA Xiao ZHANG Yu-rong QI Yuan-yuan MA Li CHEN Xue-ping WANG Jing |
| author_facet | MA Xiao ZHANG Yu-rong QI Yuan-yuan MA Li CHEN Xue-ping WANG Jing |
| author_sort | MA Xiao |
| collection | DOAJ |
| description | Objective To evaluate the Wnt/βcatenin signaling biomarkers in lupus nephritis(LN)patients.Methods Eighteen patients with lupus nephritis in Lanzhou University Second Hospital from2015 to 2016 were included,and 19 healthy people served as normal control group.The expression of Wnt1,β-cateninand DKK1 mRNA was detected by real-time polymerase chain reaction,and their plasma concentrations were determined by ELISA.Results There was no significant difference in plasma levels and mRNA expression of Wnt1,β-catenin and DKK-1 between LN group and normal control group.Theserum level ofβ-catenin was significantly higher in no responsive LN patients than in responsive ones(P<0.05).Conclusions Biomarkers in Wnt/β-catenin signaling pathway may be valuable for identification of responses for LN therapy. |
| format | Article |
| id | doaj-art-12feaec7115e4e48a931ed0e87b7026d |
| institution | DOAJ |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2018-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-12feaec7115e4e48a931ed0e87b7026d2025-08-20T03:09:25ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902018-01-0127327657916166Relationship between Wnt/β-catenin signaling pathway and lupus nephritisMA XiaoZHANG Yu-rongQI Yuan-yuanMA LiCHEN Xue-pingWANG JingObjective To evaluate the Wnt/βcatenin signaling biomarkers in lupus nephritis(LN)patients.Methods Eighteen patients with lupus nephritis in Lanzhou University Second Hospital from2015 to 2016 were included,and 19 healthy people served as normal control group.The expression of Wnt1,β-cateninand DKK1 mRNA was detected by real-time polymerase chain reaction,and their plasma concentrations were determined by ELISA.Results There was no significant difference in plasma levels and mRNA expression of Wnt1,β-catenin and DKK-1 between LN group and normal control group.Theserum level ofβ-catenin was significantly higher in no responsive LN patients than in responsive ones(P<0.05).Conclusions Biomarkers in Wnt/β-catenin signaling pathway may be valuable for identification of responses for LN therapy.http://www.lcszb.com/thesisDetails?columnId=57916166&Fpath=home&index=0Wnt/β-catenin pathwayLupus nephritisBiomarkers |
| spellingShingle | MA Xiao ZHANG Yu-rong QI Yuan-yuan MA Li CHEN Xue-ping WANG Jing Relationship between Wnt/β-catenin signaling pathway and lupus nephritis Linchuang shenzangbing zazhi Wnt/β-catenin pathway Lupus nephritis Biomarkers |
| title | Relationship between Wnt/β-catenin signaling pathway and lupus nephritis |
| title_full | Relationship between Wnt/β-catenin signaling pathway and lupus nephritis |
| title_fullStr | Relationship between Wnt/β-catenin signaling pathway and lupus nephritis |
| title_full_unstemmed | Relationship between Wnt/β-catenin signaling pathway and lupus nephritis |
| title_short | Relationship between Wnt/β-catenin signaling pathway and lupus nephritis |
| title_sort | relationship between wnt β catenin signaling pathway and lupus nephritis |
| topic | Wnt/β-catenin pathway Lupus nephritis Biomarkers |
| url | http://www.lcszb.com/thesisDetails?columnId=57916166&Fpath=home&index=0 |
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