The effect of dietary micronutrient intake on abdominal aortic calcification: a study protocol for systematic review and meta-analysis
Introduction Healthy dietary choices have an important role in preventing chronic diseases such as cardiovascular disease (CVD). Increasing evidence suggests micronutrient intake (essential minerals and vitamins) is associated with abdominal aortic calcification (AAC), which is an advanced marker of...
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BMJ Publishing Group
2025-05-01
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| Series: | BMJ Open |
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| author | Meresa Berwo Mengesha Zenawi Hagos Gufue Etsay Weldekidan Tsegay Nigus Alemu Hailu |
| author_facet | Meresa Berwo Mengesha Zenawi Hagos Gufue Etsay Weldekidan Tsegay Nigus Alemu Hailu |
| author_sort | Meresa Berwo Mengesha |
| collection | DOAJ |
| description | Introduction Healthy dietary choices have an important role in preventing chronic diseases such as cardiovascular disease (CVD). Increasing evidence suggests micronutrient intake (essential minerals and vitamins) is associated with abdominal aortic calcification (AAC), which is an advanced marker of CVD. However, the existing reports seem inconsistent. Some studies reported micronutrients are associated with a lower risk of AAC, while others have reported an increased risk. Therefore, this systematic review and meta-analysis sought to summarise the available evidence on the association of dietary micronutrient intake on AAC.Methods and analysis A comprehensive systematic search of the PubMed/MEDLINE, EMBASE, Web of Science and Google Scholar databases from their inception up to September 1, 2024, will be conducted. All clinical studies that report eligible exposure/s (dietary micronutrient intake) and outcome/s (presence/severity of AAC) will be included, and this systematic review and meta-analysis protocol will be reported following the revised Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols guidelines. The risk of bias for observational studies will be assessed using the Newcastle-Ottawa Scale and publication bias will be evaluated through visual inspection of funnel plots and the Egger’s and Begg’s regression tests. The Der Simonian and Laird random-effects model meta-analysis will be calculated to provide pooled results, and the weighted risk ratio with their 95% confidence intervals will be presented.Ethics and dissemination The results will be disseminated through publishing in a peer-reviewed journal and public presentations at relevant local, national and international conferences, workshops and symposiums. Ethical approval is not required as this is a systematic review of publicly available data.PROSPERO registration numberCRD42024575902 |
| format | Article |
| id | doaj-art-12fa13e668d64fdab3ac5510f694cbb8 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-12fa13e668d64fdab3ac5510f694cbb82025-08-20T03:08:55ZengBMJ Publishing GroupBMJ Open2044-60552025-05-0115510.1136/bmjopen-2024-096551The effect of dietary micronutrient intake on abdominal aortic calcification: a study protocol for systematic review and meta-analysisMeresa Berwo Mengesha0Zenawi Hagos Gufue1Etsay Weldekidan Tsegay2Nigus Alemu Hailu3Midwifery, Adigrat University College of Health Sciences, Adrigrat, EthiopiaDepartment of Public Health, Adigrat University College of Health Sciences, Adigrat, Tigray, EthiopiaDepartment of Modern and Traditional Medicine Research, Tigray Health Research Institute, Mekele, EthiopiaDepartment of Biomedical Sciences, Adigrat University, Adigrat, Tigray, EthiopiaIntroduction Healthy dietary choices have an important role in preventing chronic diseases such as cardiovascular disease (CVD). Increasing evidence suggests micronutrient intake (essential minerals and vitamins) is associated with abdominal aortic calcification (AAC), which is an advanced marker of CVD. However, the existing reports seem inconsistent. Some studies reported micronutrients are associated with a lower risk of AAC, while others have reported an increased risk. Therefore, this systematic review and meta-analysis sought to summarise the available evidence on the association of dietary micronutrient intake on AAC.Methods and analysis A comprehensive systematic search of the PubMed/MEDLINE, EMBASE, Web of Science and Google Scholar databases from their inception up to September 1, 2024, will be conducted. All clinical studies that report eligible exposure/s (dietary micronutrient intake) and outcome/s (presence/severity of AAC) will be included, and this systematic review and meta-analysis protocol will be reported following the revised Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols guidelines. The risk of bias for observational studies will be assessed using the Newcastle-Ottawa Scale and publication bias will be evaluated through visual inspection of funnel plots and the Egger’s and Begg’s regression tests. The Der Simonian and Laird random-effects model meta-analysis will be calculated to provide pooled results, and the weighted risk ratio with their 95% confidence intervals will be presented.Ethics and dissemination The results will be disseminated through publishing in a peer-reviewed journal and public presentations at relevant local, national and international conferences, workshops and symposiums. Ethical approval is not required as this is a systematic review of publicly available data.PROSPERO registration numberCRD42024575902https://bmjopen.bmj.com/content/15/5/e096551.full |
| spellingShingle | Meresa Berwo Mengesha Zenawi Hagos Gufue Etsay Weldekidan Tsegay Nigus Alemu Hailu The effect of dietary micronutrient intake on abdominal aortic calcification: a study protocol for systematic review and meta-analysis BMJ Open |
| title | The effect of dietary micronutrient intake on abdominal aortic calcification: a study protocol for systematic review and meta-analysis |
| title_full | The effect of dietary micronutrient intake on abdominal aortic calcification: a study protocol for systematic review and meta-analysis |
| title_fullStr | The effect of dietary micronutrient intake on abdominal aortic calcification: a study protocol for systematic review and meta-analysis |
| title_full_unstemmed | The effect of dietary micronutrient intake on abdominal aortic calcification: a study protocol for systematic review and meta-analysis |
| title_short | The effect of dietary micronutrient intake on abdominal aortic calcification: a study protocol for systematic review and meta-analysis |
| title_sort | effect of dietary micronutrient intake on abdominal aortic calcification a study protocol for systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/15/5/e096551.full |
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