Epigenetic suppression of creatine kinase B in adipocytes links endoplasmic reticulum stress to obesity-associated inflammation

Epigenetic suppression of creatine kinase B in adipocytes links endoplasmic reticulum stress to obesity-associated inflammation

In white adipose tissue, disturbed creatine metabolism through reduced creatine kinase B (CKB) transcription contributes to obesity-related inflammation. However, the mechanisms regulating CKB expression in human white adipocytes remain unclear. By screening conditions perturbed in obesity, we ident...

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Bibliographic Details
Main Authors: Gianluca Renzi, Ivan Vlassakev, Mattias Hansen, Romane Higos, Simon Lecoutre, Merve Elmastas, Ondrej Hodek, Thomas Moritz, Lynn M. Alaeddine, Scott Frendo–Cumbo, Ingrid Dahlman, Alastair Kerr, Salwan Maqdasy, Niklas Mejhert, Mikael Rydén
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Molecular Metabolism
Subjects:
Creatine pathway
Glycolysis
Immunometabolism
Tunicamycin
Chromatin remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824002138
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