Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction
This paper is about a way of correction of endothelial dysfunction with the inhibitor of arginase: L-norvaline. There is an imbalance between vasoconstriction and vasodilatation factors of endothelium on...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/515047 |
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| author | Mihail V. Pokrovskiy Mihail V. Korokin Svetlana A. Tsepeleva Tatyana G. Pokrovskaya Vladimir V. Gureev Elena A. Konovalova Oleg S. Gudyrev Vladimir I. Kochkarov Liliya V. Korokina Eleonora N. Dudina Anna V. Babko Elena G. Terehova |
| author_facet | Mihail V. Pokrovskiy Mihail V. Korokin Svetlana A. Tsepeleva Tatyana G. Pokrovskaya Vladimir V. Gureev Elena A. Konovalova Oleg S. Gudyrev Vladimir I. Kochkarov Liliya V. Korokina Eleonora N. Dudina Anna V. Babko Elena G. Terehova |
| author_sort | Mihail V. Pokrovskiy |
| collection | DOAJ |
| description | This paper is
about a way of correction of endothelial
dysfunction with the inhibitor of
arginase: L-norvaline. There is an
imbalance between vasoconstriction and
vasodilatation factors of endothelium on the basis
of endothelial dysfunction. Among vasodilatation
agents, nitrogen oxide plays the basic role.
Amino acid L-arginine serves as a source of molecules of nitrogen oxide in an
organism. Because of the high activity of arginase enzyme which
catalyzes the hydrolysis of L-arginine into
ornithine and urea, the bioavailability of
nitrogen oxide decreases. The inhibitors of
arginase suppress the activity of the given enzyme,
raising and production of nitrogen oxide, preventing
the development of endothelial
dysfunction. |
| format | Article |
| id | doaj-art-12f542fcc5a34cfaacc7729b06d2437a |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-12f542fcc5a34cfaacc7729b06d2437a2025-02-03T01:12:50ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/515047515047Arginase Inhibitor in the Pharmacological Correction of Endothelial DysfunctionMihail V. Pokrovskiy0Mihail V. Korokin1Svetlana A. Tsepeleva2Tatyana G. Pokrovskaya3Vladimir V. Gureev4Elena A. Konovalova5Oleg S. Gudyrev6Vladimir I. Kochkarov7Liliya V. Korokina8Eleonora N. Dudina9Anna V. Babko10Elena G. Terehova11Department of Pharmacology and Pharmaceutical Sciences, Belgorod State University, 85 Pobeda Street, Belgorod 308015, RussiaResearch Institute of Ecological Medicine, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, RussiaDepartment of Pharmacology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, RussiaDepartment of Pharmacology and Pharmaceutical Sciences, Belgorod State University, 85 Pobeda Street, Belgorod 308015, RussiaResearch Institute of Ecological Medicine, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, RussiaDepartment of Pharmacology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, RussiaResearch Institute of Ecological Medicine, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, RussiaDepartment of Pharmacology and Pharmaceutical Sciences, Belgorod State University, 85 Pobeda Street, Belgorod 308015, RussiaDepartment of Pharmacology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, RussiaDepartment of Pharmacology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, RussiaDepartment of Pharmacology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, RussiaDepartment of Pharmacology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, RussiaThis paper is about a way of correction of endothelial dysfunction with the inhibitor of arginase: L-norvaline. There is an imbalance between vasoconstriction and vasodilatation factors of endothelium on the basis of endothelial dysfunction. Among vasodilatation agents, nitrogen oxide plays the basic role. Amino acid L-arginine serves as a source of molecules of nitrogen oxide in an organism. Because of the high activity of arginase enzyme which catalyzes the hydrolysis of L-arginine into ornithine and urea, the bioavailability of nitrogen oxide decreases. The inhibitors of arginase suppress the activity of the given enzyme, raising and production of nitrogen oxide, preventing the development of endothelial dysfunction.http://dx.doi.org/10.4061/2011/515047 |
| spellingShingle | Mihail V. Pokrovskiy Mihail V. Korokin Svetlana A. Tsepeleva Tatyana G. Pokrovskaya Vladimir V. Gureev Elena A. Konovalova Oleg S. Gudyrev Vladimir I. Kochkarov Liliya V. Korokina Eleonora N. Dudina Anna V. Babko Elena G. Terehova Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction International Journal of Hypertension |
| title | Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction |
| title_full | Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction |
| title_fullStr | Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction |
| title_full_unstemmed | Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction |
| title_short | Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction |
| title_sort | arginase inhibitor in the pharmacological correction of endothelial dysfunction |
| url | http://dx.doi.org/10.4061/2011/515047 |
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