Granulopoiesis inhibition in acute inflammation: comparative studies in healthy and leukaemic mice
It was demonstrated previously that mice undergoing an inflammatory reaction induced by subcutaneous (SC) implantation of copper rods, produce humoral factors that initially enhance, but subsequently inhibit, diffusion chamber (DC) granulopoiesis. This provided evidence that granulopoiesis is under...
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935192000267 |
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| author | Mohamad Hamood Francis Corazza Pierre Francois Bluche Hassan El Teraifi Pierre Fondu |
| author_facet | Mohamad Hamood Francis Corazza Pierre Francois Bluche Hassan El Teraifi Pierre Fondu |
| author_sort | Mohamad Hamood |
| collection | DOAJ |
| description | It was demonstrated previously that mice undergoing an inflammatory reaction induced by subcutaneous (SC) implantation of copper rods, produce humoral factors that initially enhance, but subsequently inhibit, diffusion chamber (DC) granulopoiesis. This provided evidence that granulopoiesis is under the control of both humoral stimulators and inhibitors. In order to test the granulopoietic regulatory mechanism in leukaemic mice, we investigated the regulatory role of granulopoietic humoral inhibitors during in vivo granulopoiesis. We noticed that mice suffering from acute myeloid leukaemia (AML) are unable to augment the production of these humoral inhibitory factors when acute inflammation is induced, since no change in DC cell content was observed with or without prior inflammation. Moreover, unlike healthy mice, the serum of leukaemic mice withdrawn during the inhibition phase of acute inflammation did not show any inhibitory activity toward granulocyte—monocyte (GM) colony growth in vitro. Our results also show that increased levels of normal humoral inhibitors do not influence the proliferation and/or differentiation of leukaemic cells implanted in diffusion chamber cultures. |
| format | Article |
| id | doaj-art-12f4f15ca1944bf9bff7e7c3b5dca6b6 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-12f4f15ca1944bf9bff7e7c3b5dca6b62025-08-20T03:55:44ZengWileyMediators of Inflammation0962-93511466-18611992-01-011317117510.1155/S0962935192000267Granulopoiesis inhibition in acute inflammation: comparative studies in healthy and leukaemic miceMohamad Hamood0Francis Corazza1Pierre Francois Bluche2Hassan El Teraifi3Pierre Fondu4Experimental Hematology Laboratories of Brugmann University Hospital and Joseph Bracops Hospital, Free University of Brussels, Place Van Gehuchten 4, Brussels 1020, BelgiumExperimental Hematology Laboratories of Brugmann University Hospital and Joseph Bracops Hospital, Free University of Brussels, Place Van Gehuchten 4, Brussels 1020, BelgiumExperimental Hematology Laboratories of Brugmann University Hospital and Joseph Bracops Hospital, Free University of Brussels, Place Van Gehuchten 4, Brussels 1020, BelgiumDepartment of Histopathology, Christie Hospital, Manchester, UKExperimental Hematology Laboratories of Brugmann University Hospital and Joseph Bracops Hospital, Free University of Brussels, Place Van Gehuchten 4, Brussels 1020, BelgiumIt was demonstrated previously that mice undergoing an inflammatory reaction induced by subcutaneous (SC) implantation of copper rods, produce humoral factors that initially enhance, but subsequently inhibit, diffusion chamber (DC) granulopoiesis. This provided evidence that granulopoiesis is under the control of both humoral stimulators and inhibitors. In order to test the granulopoietic regulatory mechanism in leukaemic mice, we investigated the regulatory role of granulopoietic humoral inhibitors during in vivo granulopoiesis. We noticed that mice suffering from acute myeloid leukaemia (AML) are unable to augment the production of these humoral inhibitory factors when acute inflammation is induced, since no change in DC cell content was observed with or without prior inflammation. Moreover, unlike healthy mice, the serum of leukaemic mice withdrawn during the inhibition phase of acute inflammation did not show any inhibitory activity toward granulocyte—monocyte (GM) colony growth in vitro. Our results also show that increased levels of normal humoral inhibitors do not influence the proliferation and/or differentiation of leukaemic cells implanted in diffusion chamber cultures.http://dx.doi.org/10.1155/S0962935192000267 |
| spellingShingle | Mohamad Hamood Francis Corazza Pierre Francois Bluche Hassan El Teraifi Pierre Fondu Granulopoiesis inhibition in acute inflammation: comparative studies in healthy and leukaemic mice Mediators of Inflammation |
| title | Granulopoiesis inhibition in acute inflammation: comparative studies in healthy and leukaemic mice |
| title_full | Granulopoiesis inhibition in acute inflammation: comparative studies in healthy and leukaemic mice |
| title_fullStr | Granulopoiesis inhibition in acute inflammation: comparative studies in healthy and leukaemic mice |
| title_full_unstemmed | Granulopoiesis inhibition in acute inflammation: comparative studies in healthy and leukaemic mice |
| title_short | Granulopoiesis inhibition in acute inflammation: comparative studies in healthy and leukaemic mice |
| title_sort | granulopoiesis inhibition in acute inflammation comparative studies in healthy and leukaemic mice |
| url | http://dx.doi.org/10.1155/S0962935192000267 |
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