Advancements in the treatment of Alzheimer's disease: a comprehensive review
ABSTRACT. Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and behavioral changes. Despite being the most common cause of dementia, effective treatments have been elusive. However, recent years have witnessed significant advan...
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| Format: | Article |
| Language: | English |
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Associação Neurologia Cognitiva e do Comportamento
2025-04-01
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| Series: | Dementia & Neuropsychologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642025000100302&lng=en&tlng=en |
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| _version_ | 1850215283858341888 |
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| author | Srushti Rajanna Prajwal Pradeep Gundale Apoorva Dev Mahadevaiah |
| author_facet | Srushti Rajanna Prajwal Pradeep Gundale Apoorva Dev Mahadevaiah |
| author_sort | Srushti Rajanna |
| collection | DOAJ |
| description | ABSTRACT. Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and behavioral changes. Despite being the most common cause of dementia, effective treatments have been elusive. However, recent years have witnessed significant advancements in understanding and treating Alzheimer's. Key to these advancements is the shift toward targeted therapies tailored to individual genetic and biomarker profiles, promising more effective outcomes while minimizing side effects. The integration of advanced neuroimaging techniques has revolutionized early diagnosis and disease monitoring, enabling proactive intervention strategies that may alter disease trajectories. This review provides an overview of these advancements, focusing on disease-modifying therapies, symptomatic treatments, combination therapies, lifestyle interventions, biomarker development, innovative drug delivery systems, immunotherapy, gene therapy, and neuroprotective agents. |
| format | Article |
| id | doaj-art-12f43ef9ff484af7b876aa4111cf7c9d |
| institution | OA Journals |
| issn | 1980-5764 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj-art-12f43ef9ff484af7b876aa4111cf7c9d2025-08-20T02:08:40ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57642025-04-011910.1590/1980-5764-dn-2024-0204Advancements in the treatment of Alzheimer's disease: a comprehensive reviewSrushti Rajannahttps://orcid.org/0009-0003-2005-3433Prajwal Pradeep Gundalehttps://orcid.org/0009-0004-3634-7839Apoorva Dev Mahadevaiahhttps://orcid.org/0000-0002-5094-4443ABSTRACT. Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and behavioral changes. Despite being the most common cause of dementia, effective treatments have been elusive. However, recent years have witnessed significant advancements in understanding and treating Alzheimer's. Key to these advancements is the shift toward targeted therapies tailored to individual genetic and biomarker profiles, promising more effective outcomes while minimizing side effects. The integration of advanced neuroimaging techniques has revolutionized early diagnosis and disease monitoring, enabling proactive intervention strategies that may alter disease trajectories. This review provides an overview of these advancements, focusing on disease-modifying therapies, symptomatic treatments, combination therapies, lifestyle interventions, biomarker development, innovative drug delivery systems, immunotherapy, gene therapy, and neuroprotective agents.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642025000100302&lng=en&tlng=enAlzheimer DiseaseNeuroprotective AgentsNeuroimagingGenetic TherapyBiomarkers |
| spellingShingle | Srushti Rajanna Prajwal Pradeep Gundale Apoorva Dev Mahadevaiah Advancements in the treatment of Alzheimer's disease: a comprehensive review Dementia & Neuropsychologia Alzheimer Disease Neuroprotective Agents Neuroimaging Genetic Therapy Biomarkers |
| title | Advancements in the treatment of Alzheimer's disease: a comprehensive review |
| title_full | Advancements in the treatment of Alzheimer's disease: a comprehensive review |
| title_fullStr | Advancements in the treatment of Alzheimer's disease: a comprehensive review |
| title_full_unstemmed | Advancements in the treatment of Alzheimer's disease: a comprehensive review |
| title_short | Advancements in the treatment of Alzheimer's disease: a comprehensive review |
| title_sort | advancements in the treatment of alzheimer s disease a comprehensive review |
| topic | Alzheimer Disease Neuroprotective Agents Neuroimaging Genetic Therapy Biomarkers |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642025000100302&lng=en&tlng=en |
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