A Case Series of Recreational Ketamine-Induced Cholangiopathy
Ketamine, a dissociative anesthetic, is growing in popularity among young adults as a “club drug” in the U.S. Chronic use may lead to dependence and withdrawal symptoms, but ketamine also has been associated with ulcerative cystitis. We describe severe cholestasis and cholangiopathy in 6 young adult...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2024-07-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0993 |
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| Summary: | Ketamine, a dissociative anesthetic, is growing in popularity among young adults as a “club drug” in the U.S. Chronic use may lead to dependence and withdrawal symptoms, but ketamine also has been associated with ulcerative cystitis. We describe severe cholestasis and cholangiopathy in 6 young adults with chronic recreational ketamine use. All presented with progressive abdominal pain and cholestasis, sometimes with concomitant urinary symptoms and weight loss. In each case, there was marked biliary duct dilatation without evidence of obstruction, suggestive of sclerosing cholangitis. In some cases, the biliary duct dilatation was reversible with cessation of ketamine use. |
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| ISSN: | 2767-7664 |