Levels of Inflammatory Cytokines in Type 2 Diabetes Patients with Different Urinary Albumin Excretion Rates and Their Correlation with Clinical Variables
Although the pathogenetic mechanism of DN has not been elucidated, an inflammatory mechanism has been suggested as a potential contributor. This study was designed to explore the relationship between low-grade inflammation and renal microangiopathy in T2DM. A total of 261 diabetic subjects were divi...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/138969 |
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| author | Fen-qin Chen Jiao Wang Xiao-bo Liu Xiao-yu Ma Xiu-bin Zhang Ting Huang Dong-wei Ma Qiu-yue Wang |
| author_facet | Fen-qin Chen Jiao Wang Xiao-bo Liu Xiao-yu Ma Xiu-bin Zhang Ting Huang Dong-wei Ma Qiu-yue Wang |
| author_sort | Fen-qin Chen |
| collection | DOAJ |
| description | Although the pathogenetic mechanism of DN has not been elucidated, an inflammatory mechanism has been suggested as a potential contributor. This study was designed to explore the relationship between low-grade inflammation and renal microangiopathy in T2DM. A total of 261 diabetic subjects were divided into three groups according to UAE: a normal albuminuria group, a microalbuminuria group, and a macroalbuminuria group. A control group was also chosen. Levels of hs-CRP, TNF-α, uMCP-1, SAA, SCr, BUN, serum lipid, blood pressure, and HbA1c were measured in all subjects. Compared with the normal controls, levels of hs-CRP, TNF-α, uMCP-1, and SAA in T2DM patients were significantly higher. They were also elevated in the normal albuminuria group, P<0.05. Compared with the normal albuminuria group, levels of these inflammatory cytokines were significantly higher in the microalbuminuria and macroalbuminuria group, P<0.01. The macroalbuminuria group also showed higher levels than the microalbuminuria group, P<0.01. Also they were positively correlated with UAE, SBP, DBP, LDL-C, and TC. We noted no significance correlated with course, TG, or HDL-C. Only TNF-α; was positively correlated with HbA1c. This study revealed the importance of these inflammatory cytokines in DN pathogenesis. Further studies are needed to fully establish the potential of these cytokines as additional biomarkers for the development of DN. |
| format | Article |
| id | doaj-art-12eea5f4d3cb4233a708524e0f76dea6 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-12eea5f4d3cb4233a708524e0f76dea62025-02-03T05:51:19ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/138969138969Levels of Inflammatory Cytokines in Type 2 Diabetes Patients with Different Urinary Albumin Excretion Rates and Their Correlation with Clinical VariablesFen-qin Chen0Jiao Wang1Xiao-bo Liu2Xiao-yu Ma3Xiu-bin Zhang4Ting Huang5Dong-wei Ma6Qiu-yue Wang7Department of Geriatrics, The First Affiliated Hospital, China Medical University, Shenyang 110001, ChinaDepartment of Endocrinology, Fengtian Hospital of Shenyang Medical College, Shenyang 110000, ChinaDepartment of Geriatrics, The First Affiliated Hospital, China Medical University, Shenyang 110001, ChinaDepartment of Geriatrics, The First Affiliated Hospital, China Medical University, Shenyang 110001, ChinaDepartment of Endocrinology, The Fourth People’s Hospital of Shenyang, Shenyang 110031, ChinaDepartment of Geriatrics, The First Affiliated Hospital, China Medical University, Shenyang 110001, ChinaDepartment of Endocrinology, The First Affiliated Hospital, China Medical University, Shenyang 110001, ChinaDepartment of Endocrinology, The First Affiliated Hospital, China Medical University, Shenyang 110001, ChinaAlthough the pathogenetic mechanism of DN has not been elucidated, an inflammatory mechanism has been suggested as a potential contributor. This study was designed to explore the relationship between low-grade inflammation and renal microangiopathy in T2DM. A total of 261 diabetic subjects were divided into three groups according to UAE: a normal albuminuria group, a microalbuminuria group, and a macroalbuminuria group. A control group was also chosen. Levels of hs-CRP, TNF-α, uMCP-1, SAA, SCr, BUN, serum lipid, blood pressure, and HbA1c were measured in all subjects. Compared with the normal controls, levels of hs-CRP, TNF-α, uMCP-1, and SAA in T2DM patients were significantly higher. They were also elevated in the normal albuminuria group, P<0.05. Compared with the normal albuminuria group, levels of these inflammatory cytokines were significantly higher in the microalbuminuria and macroalbuminuria group, P<0.01. The macroalbuminuria group also showed higher levels than the microalbuminuria group, P<0.01. Also they were positively correlated with UAE, SBP, DBP, LDL-C, and TC. We noted no significance correlated with course, TG, or HDL-C. Only TNF-α; was positively correlated with HbA1c. This study revealed the importance of these inflammatory cytokines in DN pathogenesis. Further studies are needed to fully establish the potential of these cytokines as additional biomarkers for the development of DN.http://dx.doi.org/10.1155/2013/138969 |
| spellingShingle | Fen-qin Chen Jiao Wang Xiao-bo Liu Xiao-yu Ma Xiu-bin Zhang Ting Huang Dong-wei Ma Qiu-yue Wang Levels of Inflammatory Cytokines in Type 2 Diabetes Patients with Different Urinary Albumin Excretion Rates and Their Correlation with Clinical Variables Journal of Diabetes Research |
| title | Levels of Inflammatory Cytokines in Type 2 Diabetes Patients with Different Urinary Albumin Excretion Rates and Their Correlation with Clinical Variables |
| title_full | Levels of Inflammatory Cytokines in Type 2 Diabetes Patients with Different Urinary Albumin Excretion Rates and Their Correlation with Clinical Variables |
| title_fullStr | Levels of Inflammatory Cytokines in Type 2 Diabetes Patients with Different Urinary Albumin Excretion Rates and Their Correlation with Clinical Variables |
| title_full_unstemmed | Levels of Inflammatory Cytokines in Type 2 Diabetes Patients with Different Urinary Albumin Excretion Rates and Their Correlation with Clinical Variables |
| title_short | Levels of Inflammatory Cytokines in Type 2 Diabetes Patients with Different Urinary Albumin Excretion Rates and Their Correlation with Clinical Variables |
| title_sort | levels of inflammatory cytokines in type 2 diabetes patients with different urinary albumin excretion rates and their correlation with clinical variables |
| url | http://dx.doi.org/10.1155/2013/138969 |
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