Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs

Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs

This review evaluates the current state of C/D snoRNA databases and prediction tools in relation to 2’-O-methylation (2'-O-Me). It highlights the limitations of existing resources in accurately annotating and predicting guide snoRNAs, particularly for newly identified 2’-O-Me sites. We emphasiz...

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Bibliographic Details
Main Authors: Christian Ramirez, Elena Perenthaler, Fabio Lauria, Toma Tebaldi, Gabriella Viero
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:RNA Biology
Subjects:
C/D snoRNA
2’-O-methylation
Nm
ribosome
translation
RNA
Online Access:https://www.tandfonline.com/doi/10.1080/15476286.2025.2506712
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