Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs
This review evaluates the current state of C/D snoRNA databases and prediction tools in relation to 2’-O-methylation (2'-O-Me). It highlights the limitations of existing resources in accurately annotating and predicting guide snoRNAs, particularly for newly identified 2’-O-Me sites. We emphasiz...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | RNA Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2025.2506712 |
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| author | Christian Ramirez Elena Perenthaler Fabio Lauria Toma Tebaldi Gabriella Viero |
| author_facet | Christian Ramirez Elena Perenthaler Fabio Lauria Toma Tebaldi Gabriella Viero |
| author_sort | Christian Ramirez |
| collection | DOAJ |
| description | This review evaluates the current state of C/D snoRNA databases and prediction tools in relation to 2’-O-methylation (2'-O-Me). It highlights the limitations of existing resources in accurately annotating and predicting guide snoRNAs, particularly for newly identified 2’-O-Me sites. We emphasize the need for advanced computational approaches specifically tailored to 2’-O-Me to enable the discovery and functional analysis of snoRNAs. Given the growing importance of 2’-O-Me in areas such as cancer epitranscriptomics, ribosome biogenesis, and heterogeneity, existing tools remain inadequate. As 2’-O-Me gains recognition as a potential biomarker and therapeutic target, more sophisticated methods are urgently needed to improve snoRNA annotation and prediction, facilitating biomedical advancements. |
| format | Article |
| id | doaj-art-12ec2fa29076476cac09fc5ec9788952 |
| institution | DOAJ |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-12ec2fa29076476cac09fc5ec97889522025-08-20T03:15:54ZengTaylor & Francis GroupRNA Biology1547-62861555-85842025-12-0122111110.1080/15476286.2025.2506712Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAsChristian Ramirez0Elena Perenthaler1Fabio Lauria2Toma Tebaldi3Gabriella Viero4Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, ItalyInstitute of Biophysics CNR Unit at Trento, Trento ItalyInstitute of Biophysics CNR Unit at Trento, Trento ItalyDepartment of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, ItalyInstitute of Biophysics CNR Unit at Trento, Trento ItalyThis review evaluates the current state of C/D snoRNA databases and prediction tools in relation to 2’-O-methylation (2'-O-Me). It highlights the limitations of existing resources in accurately annotating and predicting guide snoRNAs, particularly for newly identified 2’-O-Me sites. We emphasize the need for advanced computational approaches specifically tailored to 2’-O-Me to enable the discovery and functional analysis of snoRNAs. Given the growing importance of 2’-O-Me in areas such as cancer epitranscriptomics, ribosome biogenesis, and heterogeneity, existing tools remain inadequate. As 2’-O-Me gains recognition as a potential biomarker and therapeutic target, more sophisticated methods are urgently needed to improve snoRNA annotation and prediction, facilitating biomedical advancements.https://www.tandfonline.com/doi/10.1080/15476286.2025.2506712C/D snoRNA2’-O-methylationNmribosometranslationRNA |
| spellingShingle | Christian Ramirez Elena Perenthaler Fabio Lauria Toma Tebaldi Gabriella Viero Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs RNA Biology C/D snoRNA 2’-O-methylation Nm ribosome translation RNA |
| title | Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs |
| title_full | Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs |
| title_fullStr | Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs |
| title_full_unstemmed | Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs |
| title_short | Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs |
| title_sort | computational limitations and future needs to unravel the full potential of 2 o methylation and c d box snornas |
| topic | C/D snoRNA 2’-O-methylation Nm ribosome translation RNA |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2025.2506712 |
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