Impact of prostate cancer screening in European ancestry un‐affected men with germline DNA repair pathogenic variants

Impact of prostate cancer screening in European ancestry un‐affected men with germline DNA repair pathogenic variants

Abstract Background and Objective Prostate cancer (PCa) is a significant global health concern, ranking as the second most prevalent cancer among men worldwide. Genetic factors, particularly germline pathogenic variants (PVs) in DNA repair genes (DRGs), play a crucial role in PCa predisposition. Our...

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Main Authors: Vittorio Fasulo, Giuseppe Chiarelli, Giuseppe Garofano, Carla Barbara Ripamonti, Monica Barile, Paolo Bianchi, Emanuela Morenghi, Alessio Benetti, Muhannad Aljoulani, Alessio Finocchiaro, Marco Paciotti, Pier Paolo Avolio, Edoardo Beatrici, Paola Arena, Alberto Saita, Rodolfo Hurle, Federica Maura, Giorgio Da Rin, Rosanna Asselta, Anita Capalbo, Giulia Soldà, Paolo Casale, Nicolò Maria Buffi, Giovanni Lughezzani, Massimo Lazzeri
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:BJUI Compass
Subjects:
BRCA 1–2
DNA‐repair gene variant
genetic risk
prostatic neoplasm
screening
Online Access:https://doi.org/10.1002/bco2.424
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