Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population
Background. Nonalcoholic fatty liver disease (NAFLD) patients are often prone to coronary artery disease (CAD), and CAD is found to be the main cause of death in NAFLD patients. The purpose of this study was to investigate the association between fatty acid desaturase 2 (FADS2) rs3834458 polymorphis...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/6069870 |
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| author | Yingyu Xu Zhenzhen Zhao Shousheng Liu Yingpu Xiao Mengyuan Miao Quanjiang Dong Yongning Xin |
| author_facet | Yingyu Xu Zhenzhen Zhao Shousheng Liu Yingpu Xiao Mengyuan Miao Quanjiang Dong Yongning Xin |
| author_sort | Yingyu Xu |
| collection | DOAJ |
| description | Background. Nonalcoholic fatty liver disease (NAFLD) patients are often prone to coronary artery disease (CAD), and CAD is found to be the main cause of death in NAFLD patients. The purpose of this study was to investigate the association between fatty acid desaturase 2 (FADS2) rs3834458 polymorphism and serum FADS2 level with NAFLD and CAD in Chinese Han population. Materials and Methods. The serum level of FADS2 was detected by enzyme-linked immunosorbent assay (ELISA) in healthy people, NAFLD patients, and NAFLD patients combined with CAD (NAFLD+CAD). Polymerase chain reaction (PCR) was used to detect the genotypes of FADS2 rs3834458 in the three groups. Results. Body mass index (BMI), glucose (GLU), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) of the NAFLD group and the NAFLD+CAD group were higher than those of the healthy control group (P<0.05); the HDL-C of the NAFLD+CAD group was significantly lower than that of the healthy people and the NAFLD group (P<0.05). The serum FADS2 concentration in the NAFLD+CAD group was significantly higher than that in the NAFLD group (P<0.05) and the healthy people (P<0.05). There was no significant difference in genotype distribution (χ2=5.347, P<0.497) and allele frequency (χ2=3.322, P=0.345) between the three groups. Logistic regression analysis showed that the T allele was not an independent risk factor for CAD with NAFLD (OR=1.62, 95% CI: 0.422-6.180). Conclusions. Serum FADS2 concentration was positively correlated with the susceptibility of NAFLD with CAD, while the polymorphism of rs3834458 was not associated with NAFLD with CAD. |
| format | Article |
| id | doaj-art-12ec06b731ec418bab1199783bb676eb |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-12ec06b731ec418bab1199783bb676eb2025-08-20T02:02:10ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/60698706069870Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han PopulationYingyu Xu0Zhenzhen Zhao1Shousheng Liu2Yingpu Xiao3Mengyuan Miao4Quanjiang Dong5Yongning Xin6The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao 266000, ChinaQingdao Municipal Hospital Central Laboratory, Qingdao 266000, ChinaQingdao Municipal Hospital Central Laboratory, Qingdao 266000, ChinaDalian Medical University, Dalian 116000, ChinaNanjing Medical University, Nanjing 210000, ChinaQingdao Key Laboratory of Digestive Diseases, Qingdao 266000, ChinaQingdao Key Laboratory of Digestive Diseases, Qingdao 266000, ChinaBackground. Nonalcoholic fatty liver disease (NAFLD) patients are often prone to coronary artery disease (CAD), and CAD is found to be the main cause of death in NAFLD patients. The purpose of this study was to investigate the association between fatty acid desaturase 2 (FADS2) rs3834458 polymorphism and serum FADS2 level with NAFLD and CAD in Chinese Han population. Materials and Methods. The serum level of FADS2 was detected by enzyme-linked immunosorbent assay (ELISA) in healthy people, NAFLD patients, and NAFLD patients combined with CAD (NAFLD+CAD). Polymerase chain reaction (PCR) was used to detect the genotypes of FADS2 rs3834458 in the three groups. Results. Body mass index (BMI), glucose (GLU), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) of the NAFLD group and the NAFLD+CAD group were higher than those of the healthy control group (P<0.05); the HDL-C of the NAFLD+CAD group was significantly lower than that of the healthy people and the NAFLD group (P<0.05). The serum FADS2 concentration in the NAFLD+CAD group was significantly higher than that in the NAFLD group (P<0.05) and the healthy people (P<0.05). There was no significant difference in genotype distribution (χ2=5.347, P<0.497) and allele frequency (χ2=3.322, P=0.345) between the three groups. Logistic regression analysis showed that the T allele was not an independent risk factor for CAD with NAFLD (OR=1.62, 95% CI: 0.422-6.180). Conclusions. Serum FADS2 concentration was positively correlated with the susceptibility of NAFLD with CAD, while the polymorphism of rs3834458 was not associated with NAFLD with CAD.http://dx.doi.org/10.1155/2019/6069870 |
| spellingShingle | Yingyu Xu Zhenzhen Zhao Shousheng Liu Yingpu Xiao Mengyuan Miao Quanjiang Dong Yongning Xin Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population Gastroenterology Research and Practice |
| title | Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population |
| title_full | Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population |
| title_fullStr | Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population |
| title_full_unstemmed | Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population |
| title_short | Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population |
| title_sort | association of nonalcoholic fatty liver disease and coronary artery disease with fads2 rs3834458 gene polymorphism in the chinese han population |
| url | http://dx.doi.org/10.1155/2019/6069870 |
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