Health- related quality of life after surgery for spinal metastases
Background: Surgery for spinal metastases is almost always palliative and part of a multidisciplinary approach that has determined a significant increase of life expectancy in the last decade; thus, an improvement in health-related quality of life (HRQOL) is the main goal of the treatment of spinal...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Journal of Bone Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212137425000168 |
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| author | Silvia Terzi Cristiana Griffoni Simona Rosa Chiara Cini Emanuela Asunis Chiara Alcherigi Federica Trentin Stefano Bandiera Riccardo Ghermandi Giuseppe Tedesco Gisberto Evangelisti Marco Girolami Valerio Pipola Giovanni Barbanti Brodano Alessandro Gasbarrini |
| author_facet | Silvia Terzi Cristiana Griffoni Simona Rosa Chiara Cini Emanuela Asunis Chiara Alcherigi Federica Trentin Stefano Bandiera Riccardo Ghermandi Giuseppe Tedesco Gisberto Evangelisti Marco Girolami Valerio Pipola Giovanni Barbanti Brodano Alessandro Gasbarrini |
| author_sort | Silvia Terzi |
| collection | DOAJ |
| description | Background: Surgery for spinal metastases is almost always palliative and part of a multidisciplinary approach that has determined a significant increase of life expectancy in the last decade; thus, an improvement in health-related quality of life (HRQOL) is the main goal of the treatment of spinal metastases. We report here the results of a prospective study conducted with the aim of evaluating the impact of spinal surgery on HRQOL, measured by Patient-Reported Outcomes Measures (PROMs). We analyzed clinical outcomes (ambulatory status, performance status, pain, neurological status) and HRQOL scores (VAS, EQ5D, SF36) during the follow-up period and focused on factors that could affect quality of life, considering both psychological and physical issues. Methods: 169 patients (96 males, 73 females) with vertebral metastases who underwent surgery at a tertiary referral center were consecutively enrolled from August 2018 to October 2022. Clinical and surgical data were prospectively collected, and PROMs (VAS, EQ-5D and SF-36) were registered before surgery and during follow up. Results: The overall survival was 22 months, and a 61 % survival rate was registered at 1 year follow-up. We observed a significant improvement in walking ability, general performance status, pain and HRQOL after surgery, which was maintained during the follow up. Multivariate analysis identified three independent variables, capable of influencing the trend of HRQOL after surgery: the presence of pathological fracture, the preoperative neurological status and the local recurrence of disease. Discussion: This study confirms the effectiveness of surgery for spinal metastases in improving patients’ performance status and demonstrates an overall improvement in HRQOL, which is maintained over time. |
| format | Article |
| id | doaj-art-12eb68af90b8452f85fb52ac4ea5e5d4 |
| institution | DOAJ |
| issn | 2212-1374 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Bone Oncology |
| spelling | doaj-art-12eb68af90b8452f85fb52ac4ea5e5d42025-08-20T03:20:33ZengElsevierJournal of Bone Oncology2212-13742025-06-015210067510.1016/j.jbo.2025.100675Health- related quality of life after surgery for spinal metastasesSilvia Terzi0Cristiana Griffoni1Simona Rosa2Chiara Cini3Emanuela Asunis4Chiara Alcherigi5Federica Trentin6Stefano Bandiera7Riccardo Ghermandi8Giuseppe Tedesco9Gisberto Evangelisti10Marco Girolami11Valerio Pipola12Giovanni Barbanti Brodano13Alessandro Gasbarrini14Department of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; Corresponding author.Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyUO Neuropsichiatria dell’età pediatrica, IRCCS Istituto delle Scienze Neurologiche di Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, Bologna, ItalyBackground: Surgery for spinal metastases is almost always palliative and part of a multidisciplinary approach that has determined a significant increase of life expectancy in the last decade; thus, an improvement in health-related quality of life (HRQOL) is the main goal of the treatment of spinal metastases. We report here the results of a prospective study conducted with the aim of evaluating the impact of spinal surgery on HRQOL, measured by Patient-Reported Outcomes Measures (PROMs). We analyzed clinical outcomes (ambulatory status, performance status, pain, neurological status) and HRQOL scores (VAS, EQ5D, SF36) during the follow-up period and focused on factors that could affect quality of life, considering both psychological and physical issues. Methods: 169 patients (96 males, 73 females) with vertebral metastases who underwent surgery at a tertiary referral center were consecutively enrolled from August 2018 to October 2022. Clinical and surgical data were prospectively collected, and PROMs (VAS, EQ-5D and SF-36) were registered before surgery and during follow up. Results: The overall survival was 22 months, and a 61 % survival rate was registered at 1 year follow-up. We observed a significant improvement in walking ability, general performance status, pain and HRQOL after surgery, which was maintained during the follow up. Multivariate analysis identified three independent variables, capable of influencing the trend of HRQOL after surgery: the presence of pathological fracture, the preoperative neurological status and the local recurrence of disease. Discussion: This study confirms the effectiveness of surgery for spinal metastases in improving patients’ performance status and demonstrates an overall improvement in HRQOL, which is maintained over time.http://www.sciencedirect.com/science/article/pii/S2212137425000168Spinal metastasesSurgical treatmentHealth-related quality of lifePatient Reported Outcomes |
| spellingShingle | Silvia Terzi Cristiana Griffoni Simona Rosa Chiara Cini Emanuela Asunis Chiara Alcherigi Federica Trentin Stefano Bandiera Riccardo Ghermandi Giuseppe Tedesco Gisberto Evangelisti Marco Girolami Valerio Pipola Giovanni Barbanti Brodano Alessandro Gasbarrini Health- related quality of life after surgery for spinal metastases Journal of Bone Oncology Spinal metastases Surgical treatment Health-related quality of life Patient Reported Outcomes |
| title | Health- related quality of life after surgery for spinal metastases |
| title_full | Health- related quality of life after surgery for spinal metastases |
| title_fullStr | Health- related quality of life after surgery for spinal metastases |
| title_full_unstemmed | Health- related quality of life after surgery for spinal metastases |
| title_short | Health- related quality of life after surgery for spinal metastases |
| title_sort | health related quality of life after surgery for spinal metastases |
| topic | Spinal metastases Surgical treatment Health-related quality of life Patient Reported Outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S2212137425000168 |
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