Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aP
Chronic Kidney Disease-associated Pruritus (CKD-aP) is a debilitating condition commonly observed in patients with chronic kidney disease (CKD), characterized by severe skin itching and inflammation. Despite the availability of oral medications and topical treatments, their efficacy is limited, and...
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259000642500403X |
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| author | Lichang Liu Longbao Feng Yuanyuan Zhang Junjie Xu Le Liu Lichun Wang Weihong Hong Yuyan Jin Jiahao Zeng Peihua He Xusheng Liu |
| author_facet | Lichang Liu Longbao Feng Yuanyuan Zhang Junjie Xu Le Liu Lichun Wang Weihong Hong Yuyan Jin Jiahao Zeng Peihua He Xusheng Liu |
| author_sort | Lichang Liu |
| collection | DOAJ |
| description | Chronic Kidney Disease-associated Pruritus (CKD-aP) is a debilitating condition commonly observed in patients with chronic kidney disease (CKD), characterized by severe skin itching and inflammation. Despite the availability of oral medications and topical treatments, their efficacy is limited, and systemic side effects are a significant concern. This study presents the development of a novel microneedle system (Cap@Lip/Dife-MNs), designed to address CKD-aP through targeted and sustained drug delivery. The system integrates liposome-encapsulated capsaicin, known for its anti-inflammatory and analgesic effects, with methacryloyl sericin (SerMA) hydrogel-loaded Difelikefalin, a drug that modulates neural transmission and immune responses. Liposomes enhance the solubility and stability of capsaicin, while the SerMA hydrogel provides sustained release of Difelikefalin. The Cap@Lip/Dife-MNs system demonstrates excellent drug delivery capabilities, promoting skin cell proliferation, reducing oxidative stress, and alleviating pruritus by modulating neural signaling pathways. In vivo transcriptomic analysis revealed significant modulation of immune-related genes and reduction of oxidative stress markers, confirming its immune-regulatory and anti-inflammatory effects. Moreover, neural signal analysis showed reduced pruritus-related transmission, emphasizing its potential as a non-invasive, effective treatment for CKD-aP. These findings highlight the Cap@Lip/Dife-MNs microneedle system as a promising therapeutic platform for CKD-aP, with strong potential for clinical application. |
| format | Article |
| id | doaj-art-12e8e3dcd5da4250a72a0cb8d5de2ba7 |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-12e8e3dcd5da4250a72a0cb8d5de2ba72025-08-20T02:58:25ZengElsevierMaterials Today Bio2590-00642025-06-013210184310.1016/j.mtbio.2025.101843Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aPLichang Liu0Longbao Feng1Yuanyuan Zhang2Junjie Xu3Le Liu4Lichun Wang5Weihong Hong6Yuyan Jin7Jiahao Zeng8Peihua He9Xusheng Liu10Department of Nephrology, Zhuhai Hospital of Guangdong Provincial Hospital of Chinese Medicine, Zhuhai, 519015, ChinaKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, ChinaSecond Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510006, ChinaSecond Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510006, ChinaSecond Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510006, ChinaDepartment of Nephrology, Zhuhai Hospital of Guangdong Provincial Hospital of Chinese Medicine, Zhuhai, 519015, ChinaDepartment of Nephrology, Zhuhai Hospital of Guangdong Provincial Hospital of Chinese Medicine, Zhuhai, 519015, ChinaDepartment of Nephrology, Zhuhai Hospital of Guangdong Provincial Hospital of Chinese Medicine, Zhuhai, 519015, ChinaDepartment of Nephrology, Zhuhai Hospital of Guangdong Provincial Hospital of Chinese Medicine, Zhuhai, 519015, ChinaDepartment of Nephrology, Zhuhai Hospital of Guangdong Provincial Hospital of Chinese Medicine, Zhuhai, 519015, ChinaDepartment of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, China; Corresponding author.Chronic Kidney Disease-associated Pruritus (CKD-aP) is a debilitating condition commonly observed in patients with chronic kidney disease (CKD), characterized by severe skin itching and inflammation. Despite the availability of oral medications and topical treatments, their efficacy is limited, and systemic side effects are a significant concern. This study presents the development of a novel microneedle system (Cap@Lip/Dife-MNs), designed to address CKD-aP through targeted and sustained drug delivery. The system integrates liposome-encapsulated capsaicin, known for its anti-inflammatory and analgesic effects, with methacryloyl sericin (SerMA) hydrogel-loaded Difelikefalin, a drug that modulates neural transmission and immune responses. Liposomes enhance the solubility and stability of capsaicin, while the SerMA hydrogel provides sustained release of Difelikefalin. The Cap@Lip/Dife-MNs system demonstrates excellent drug delivery capabilities, promoting skin cell proliferation, reducing oxidative stress, and alleviating pruritus by modulating neural signaling pathways. In vivo transcriptomic analysis revealed significant modulation of immune-related genes and reduction of oxidative stress markers, confirming its immune-regulatory and anti-inflammatory effects. Moreover, neural signal analysis showed reduced pruritus-related transmission, emphasizing its potential as a non-invasive, effective treatment for CKD-aP. These findings highlight the Cap@Lip/Dife-MNs microneedle system as a promising therapeutic platform for CKD-aP, with strong potential for clinical application.http://www.sciencedirect.com/science/article/pii/S259000642500403XChronic kidney disease-related pruritusMicroneedlesAnti-inflammatoryDrug delivery |
| spellingShingle | Lichang Liu Longbao Feng Yuanyuan Zhang Junjie Xu Le Liu Lichun Wang Weihong Hong Yuyan Jin Jiahao Zeng Peihua He Xusheng Liu Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aP Materials Today Bio Chronic kidney disease-related pruritus Microneedles Anti-inflammatory Drug delivery |
| title | Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aP |
| title_full | Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aP |
| title_fullStr | Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aP |
| title_full_unstemmed | Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aP |
| title_short | Nanoliposome-sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ROS for the treatment of CKD-aP |
| title_sort | nanoliposome sericin hydrogel microneedle patches effectively alleviate inflammation and scavenge ros for the treatment of ckd ap |
| topic | Chronic kidney disease-related pruritus Microneedles Anti-inflammatory Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S259000642500403X |
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