A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma
We report a case of mixed adenoneuroendocrine carcinoma (MANEC) of stomach with tubular adenoma and well-differentiated neuroendocrine tumor (WD-NET) in the primary tumor in the stomach giving rise to biphenotypic regional nodal metastases. A 35-year-old woman with abdominal pain was found to have a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/9063634 |
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| author | Javier De Luca-Johnson Maryam Zenali |
| author_facet | Javier De Luca-Johnson Maryam Zenali |
| author_sort | Javier De Luca-Johnson |
| collection | DOAJ |
| description | We report a case of mixed adenoneuroendocrine carcinoma (MANEC) of stomach with tubular adenoma and well-differentiated neuroendocrine tumor (WD-NET) in the primary tumor in the stomach giving rise to biphenotypic regional nodal metastases. A 35-year-old woman with abdominal pain was found to have a 1.8-cm gastric lesion, diagnosed as WD-NET (intermediate grade) on the biopsy. The resection specimen contained residual WD-NET; there was also a gastric adenoma adjacent to the NET and nodal metastasis with both adeno- and neuroendocrine components. The tumor was classified as MANEC. Of note, the entire gastric tissue was submitted and multiple deeper levels of the adenomatous lesion were examined; no adenocarcinoma was present in the primary lesion. While association of gastric adenoma with neuroendocrine neoplasm is rare, presence of biphenotypic metastasis originating from such a lesion is highly unusual and to the best of our knowledge has not been reported. |
| format | Article |
| id | doaj-art-12e79ad4f0cd4e11a03489bbbac714e9 |
| institution | OA Journals |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-12e79ad4f0cd4e11a03489bbbac714e92025-08-20T02:02:10ZengWileyCase Reports in Pathology2090-67812090-679X2016-01-01201610.1155/2016/90636349063634A Previously Undescribed Presentation of Mixed Adenoneuroendocrine CarcinomaJavier De Luca-Johnson0Maryam Zenali1Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, 111 Colchester Ave., Burlington, VT 05401, USADepartment of Pathology and Laboratory Medicine, University of Vermont Medical Center, 111 Colchester Ave., Burlington, VT 05401, USAWe report a case of mixed adenoneuroendocrine carcinoma (MANEC) of stomach with tubular adenoma and well-differentiated neuroendocrine tumor (WD-NET) in the primary tumor in the stomach giving rise to biphenotypic regional nodal metastases. A 35-year-old woman with abdominal pain was found to have a 1.8-cm gastric lesion, diagnosed as WD-NET (intermediate grade) on the biopsy. The resection specimen contained residual WD-NET; there was also a gastric adenoma adjacent to the NET and nodal metastasis with both adeno- and neuroendocrine components. The tumor was classified as MANEC. Of note, the entire gastric tissue was submitted and multiple deeper levels of the adenomatous lesion were examined; no adenocarcinoma was present in the primary lesion. While association of gastric adenoma with neuroendocrine neoplasm is rare, presence of biphenotypic metastasis originating from such a lesion is highly unusual and to the best of our knowledge has not been reported.http://dx.doi.org/10.1155/2016/9063634 |
| spellingShingle | Javier De Luca-Johnson Maryam Zenali A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma Case Reports in Pathology |
| title | A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma |
| title_full | A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma |
| title_fullStr | A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma |
| title_full_unstemmed | A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma |
| title_short | A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma |
| title_sort | previously undescribed presentation of mixed adenoneuroendocrine carcinoma |
| url | http://dx.doi.org/10.1155/2016/9063634 |
| work_keys_str_mv | AT javierdelucajohnson apreviouslyundescribedpresentationofmixedadenoneuroendocrinecarcinoma AT maryamzenali apreviouslyundescribedpresentationofmixedadenoneuroendocrinecarcinoma AT javierdelucajohnson previouslyundescribedpresentationofmixedadenoneuroendocrinecarcinoma AT maryamzenali previouslyundescribedpresentationofmixedadenoneuroendocrinecarcinoma |