Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical Consideration
We present a case of 16-year-old male, who was referred from private centre for dyspnoea, fatigue, and orthopnea. The chest radiograph revealed complete opacification of left chest which was confirmed by computed tomography as a large left mediastinal mass measuring 14 × 15 × 18 cm. The diagnostic n...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2016/7615029 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850235663926951936 |
|---|---|
| author | Firdaus Hayati Nurayub Mohd Ali Levin Kesu Belani Nornazirah Azizan Andee Dzulkarnaen Zakaria Mohd Ramzisham Abdul Rahman |
| author_facet | Firdaus Hayati Nurayub Mohd Ali Levin Kesu Belani Nornazirah Azizan Andee Dzulkarnaen Zakaria Mohd Ramzisham Abdul Rahman |
| author_sort | Firdaus Hayati |
| collection | DOAJ |
| description | We present a case of 16-year-old male, who was referred from private centre for dyspnoea, fatigue, and orthopnea. The chest radiograph revealed complete opacification of left chest which was confirmed by computed tomography as a large left mediastinal mass measuring 14 × 15 × 18 cm. The diagnostic needle core biopsy revealed mixed germ cell tumour with possible combination of embryonal carcinoma, yolk sac, and teratoma. After 4 cycles of neoadjuvant BEP regime, there was initial response of tumour markers but not tumour bulk. Instead of classic median sternotomy or clamshell incision, posterolateral approach with piecemeal manner was chosen. Histology confirmed mixed germ cell tumour with residual teratomatous component without yolk sac or embryonal carcinoma component. Weighing 3.5 kg, it is one of the largest mediastinal germ cell tumours ever reported. We describe this rare and gigantic intrathoracic tumour and discuss the spectrum of surgical approach and treatment of this exceptional tumour. |
| format | Article |
| id | doaj-art-12e5d6f83f684d2ea35d8b8d9ced8e6f |
| institution | OA Journals |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-12e5d6f83f684d2ea35d8b8d9ced8e6f2025-08-20T02:02:10ZengWileyCase Reports in Surgery2090-69002090-69192016-01-01201610.1155/2016/76150297615029Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical ConsiderationFirdaus Hayati0Nurayub Mohd Ali1Levin Kesu Belani2Nornazirah Azizan3Andee Dzulkarnaen Zakaria4Mohd Ramzisham Abdul Rahman5Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, MalaysiaDepartment of Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaDepartment of Pathobiology and Medical Diagnostic, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, MalaysiaDepartment of Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, MalaysiaDepartment of Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MalaysiaWe present a case of 16-year-old male, who was referred from private centre for dyspnoea, fatigue, and orthopnea. The chest radiograph revealed complete opacification of left chest which was confirmed by computed tomography as a large left mediastinal mass measuring 14 × 15 × 18 cm. The diagnostic needle core biopsy revealed mixed germ cell tumour with possible combination of embryonal carcinoma, yolk sac, and teratoma. After 4 cycles of neoadjuvant BEP regime, there was initial response of tumour markers but not tumour bulk. Instead of classic median sternotomy or clamshell incision, posterolateral approach with piecemeal manner was chosen. Histology confirmed mixed germ cell tumour with residual teratomatous component without yolk sac or embryonal carcinoma component. Weighing 3.5 kg, it is one of the largest mediastinal germ cell tumours ever reported. We describe this rare and gigantic intrathoracic tumour and discuss the spectrum of surgical approach and treatment of this exceptional tumour.http://dx.doi.org/10.1155/2016/7615029 |
| spellingShingle | Firdaus Hayati Nurayub Mohd Ali Levin Kesu Belani Nornazirah Azizan Andee Dzulkarnaen Zakaria Mohd Ramzisham Abdul Rahman Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical Consideration Case Reports in Surgery |
| title | Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical Consideration |
| title_full | Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical Consideration |
| title_fullStr | Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical Consideration |
| title_full_unstemmed | Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical Consideration |
| title_short | Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical Consideration |
| title_sort | giant mediastinal germ cell tumour an enigma of surgical consideration |
| url | http://dx.doi.org/10.1155/2016/7615029 |
| work_keys_str_mv | AT firdaushayati giantmediastinalgermcelltumouranenigmaofsurgicalconsideration AT nurayubmohdali giantmediastinalgermcelltumouranenigmaofsurgicalconsideration AT levinkesubelani giantmediastinalgermcelltumouranenigmaofsurgicalconsideration AT nornazirahazizan giantmediastinalgermcelltumouranenigmaofsurgicalconsideration AT andeedzulkarnaenzakaria giantmediastinalgermcelltumouranenigmaofsurgicalconsideration AT mohdramzishamabdulrahman giantmediastinalgermcelltumouranenigmaofsurgicalconsideration |