Short course treatment regimens for multiple drug resistant tuberculosis in Arkhangelsk, Murmansk and Belgorod Regions
In 2016, World Health Organization published new guidelines for the treatment of multiple drug resistant tuberculosis (MDR TB), which stated that minimum duration of treatment was 9 months. In the Russian Federation, it is impossible to use short course 9-month treatment for MDR-TB since clofazimine...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2019-08-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1308 |
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| author | A. О. Mаryandyshev A. I. Kulizhskаya E. S. Khimovа D. V. Perkhin O. M. Sveshnikovа S. E. Presnovа N. P. Kurochkinа A. S. Sotnikov N. A. Leschevа I. A. Vаsilyevа |
| author_facet | A. О. Mаryandyshev A. I. Kulizhskаya E. S. Khimovа D. V. Perkhin O. M. Sveshnikovа S. E. Presnovа N. P. Kurochkinа A. S. Sotnikov N. A. Leschevа I. A. Vаsilyevа |
| author_sort | A. О. Mаryandyshev |
| collection | DOAJ |
| description | In 2016, World Health Organization published new guidelines for the treatment of multiple drug resistant tuberculosis (MDR TB), which stated that minimum duration of treatment was 9 months. In the Russian Federation, it is impossible to use short course 9-month treatment for MDR-TB since clofazimine is not registered in this country. The objective of the study: to compare efficacy of short course 9-month treatment of MDR-TB and the standard treatment regimen lasting 18-24 months recommended by the Russian Society of Phthisiologists (ROF). Subjects and methods. 180 MDR TB cases notified in 2015, and 179 MDR TB cases notified in 2016 were enrolled into the trial and treated for 18-24 and 12 months. respectively. Chemotherapy regimens included anti-tuberculosis drugs recommended by the ROF. With a 12-month course of treatment, an injectable drug was used for 4 months and discontinued after culture conversion. Results. The efficacy of the short course chemotherapy reached 81% and was not statistically significantly different from the results of the 18-24-month course of treatment. In the patients treated with short course chemotherapy, treatment interruption made 9.5% versus 13.3% in those treated with standard treatment. There were no statistically significant changes in treatment outcomes of both cohorts of MDR-TB patients. Relapses were registered in 6 MDR TB patients from the cohort treated by the standard regimen. |
| format | Article |
| id | doaj-art-12e5b60048f6476b89056829f71e6ef8 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2019-08-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-12e5b60048f6476b89056829f71e6ef82025-08-20T02:05:49ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062019-08-0197751010.21292/2075-1230-2019-97-7-5-101308Short course treatment regimens for multiple drug resistant tuberculosis in Arkhangelsk, Murmansk and Belgorod RegionsA. О. Mаryandyshev0A. I. Kulizhskаya1E. S. Khimovа2D. V. Perkhin3O. M. Sveshnikovа4S. E. Presnovа5N. P. Kurochkinа6A. S. Sotnikov7N. A. Leschevа8I. A. Vаsilyevа9Northern State Medical UniversityArkhangelsk Clinical TB Dispensary; Northern State Medical UniversityArkhangelsk Clinical TB Dispensary; Northern State Medical UniversityArkhangelsk Clinical TB DispensaryArkhangelsk Clinical TB DispensaryMurmansk TB DispensaryMurmansk TB DispensaryTB DispensaryTB DispensaryNational Medical Research Center of Phthisiopulmonology and Infectious DiseasesIn 2016, World Health Organization published new guidelines for the treatment of multiple drug resistant tuberculosis (MDR TB), which stated that minimum duration of treatment was 9 months. In the Russian Federation, it is impossible to use short course 9-month treatment for MDR-TB since clofazimine is not registered in this country. The objective of the study: to compare efficacy of short course 9-month treatment of MDR-TB and the standard treatment regimen lasting 18-24 months recommended by the Russian Society of Phthisiologists (ROF). Subjects and methods. 180 MDR TB cases notified in 2015, and 179 MDR TB cases notified in 2016 were enrolled into the trial and treated for 18-24 and 12 months. respectively. Chemotherapy regimens included anti-tuberculosis drugs recommended by the ROF. With a 12-month course of treatment, an injectable drug was used for 4 months and discontinued after culture conversion. Results. The efficacy of the short course chemotherapy reached 81% and was not statistically significantly different from the results of the 18-24-month course of treatment. In the patients treated with short course chemotherapy, treatment interruption made 9.5% versus 13.3% in those treated with standard treatment. There were no statistically significant changes in treatment outcomes of both cohorts of MDR-TB patients. Relapses were registered in 6 MDR TB patients from the cohort treated by the standard regimen.https://www.tibl-journal.com/jour/article/view/1308pulmonary tuberculosismdr tbshort course tuberculosis chemotherapy |
| spellingShingle | A. О. Mаryandyshev A. I. Kulizhskаya E. S. Khimovа D. V. Perkhin O. M. Sveshnikovа S. E. Presnovа N. P. Kurochkinа A. S. Sotnikov N. A. Leschevа I. A. Vаsilyevа Short course treatment regimens for multiple drug resistant tuberculosis in Arkhangelsk, Murmansk and Belgorod Regions Туберкулез и болезни лёгких pulmonary tuberculosis mdr tb short course tuberculosis chemotherapy |
| title | Short course treatment regimens for multiple drug resistant tuberculosis in Arkhangelsk, Murmansk and Belgorod Regions |
| title_full | Short course treatment regimens for multiple drug resistant tuberculosis in Arkhangelsk, Murmansk and Belgorod Regions |
| title_fullStr | Short course treatment regimens for multiple drug resistant tuberculosis in Arkhangelsk, Murmansk and Belgorod Regions |
| title_full_unstemmed | Short course treatment regimens for multiple drug resistant tuberculosis in Arkhangelsk, Murmansk and Belgorod Regions |
| title_short | Short course treatment regimens for multiple drug resistant tuberculosis in Arkhangelsk, Murmansk and Belgorod Regions |
| title_sort | short course treatment regimens for multiple drug resistant tuberculosis in arkhangelsk murmansk and belgorod regions |
| topic | pulmonary tuberculosis mdr tb short course tuberculosis chemotherapy |
| url | https://www.tibl-journal.com/jour/article/view/1308 |
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