Single cell analysis identified IFN signaling activation contributes to the pathogenesis of pediatric steroid-sensitive nephrotic syndrome

Single cell analysis identified IFN signaling activation contributes to the pathogenesis of pediatric steroid-sensitive nephrotic syndrome

Abstract Background Idiopathic nephrotic syndrome (INS) is a prevalent condition whose recurrence leads to multiple adverse effects. Previous studies on INS pathogenesis primarily focused on immune dysregulation, particularly T-cell changes and their correlation with cytokine shifts. Accumulating ev...

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Main Authors: Qiu-Yu Li, Fei Liu, Xiaoyi Li, Minchao Kang, Linnan Bai, Tong Tong, Chen Zheng, Yanyan Jin, Xiaojing Zhang, Yi Xie, Dandan Tian, Yuanqing Pan, Jingjing Wang, Haidong Fu, Na Jiao, Junnan Wu, JianHua Mao
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Biomarker Research
Subjects:
Idiopathic nephrotic syndrome
scRNA-seq
IFN
PBMCs
Online Access:https://doi.org/10.1186/s40364-025-00790-2
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