DIORS: Enhancing drug-target interaction prediction via structure and signature integrated-driven approach and discovering potential targeted molecules

DIORS: Enhancing drug-target interaction prediction via structure and signature integrated-driven approach and discovering potential targeted molecules

Drug-target interaction prediction is critical for drug development. Through the integration of structural and transcriptional signature information, molecules both binding to the target and producing therapeutic activities could be found out to improve targeted drug prediction. Therefore, the appro...

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Bibliographic Details
Main Authors: Yiran Tang, Shengqiao Gao, Dan Luo, Xuyong Jiang, Xueru Zhao, Wanting Hu, Yongxiang Zhang, Zhiyong Xiao, Lu Han, Wenxia Zhou
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Pharmacological Research
Subjects:
Drug-target interaction
Molecular docking
Signature
Structure
LINCS
Drug repurposing
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825001355
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