Correlation analysis between OCT evaluation and postoperative visual prognosis of patients with age-related macular degeneration complicated with cataract
Abstract Objective To explore the correlation between optical coherence tomography (OCT) evaluations and postoperative visual prognosis in individuals with AMD complicated with cataract, and to investigate the clinical applications of these evaluations for predicting visual outcomes. Methods We retr...
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2025-05-01
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| author | Lei Zhang Yuanxiang Luo |
| author_facet | Lei Zhang Yuanxiang Luo |
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| collection | DOAJ |
| description | Abstract Objective To explore the correlation between optical coherence tomography (OCT) evaluations and postoperative visual prognosis in individuals with AMD complicated with cataract, and to investigate the clinical applications of these evaluations for predicting visual outcomes. Methods We retrospectively analyzed the clinical data of 132 individuals (132 eyes) with AMD complicated by cataract, admitted to our hospital from April 2022 to January 2024. All patients underwent surgical treatment and were categorized into two groups based on their visual prognosis after 6 months: the “good prognosis (GP)” group (best corrected visual acuity decrease < 0.1 logMAR) and the “poor prognosis (PP)” group (best corrected visual acuity decrease ≥ 0.1 logMAR). We evaluated OCT parameters including central retinal thickness (CRT), central macular thickness (CMT), subfoveal choroidal thickness (SFCT), and total average macular thickness (TR). Pearson correlation analysis was employed to assess the relationship between these OCT parameters and postoperative visual outcomes. Additionally, receiver operating characteristic (ROC) were used to calculate the predictive value of OCT measurements for identifying poor postoperative visual prognosis in this patient cohort. Results Preoperative OCT results showed significantly higher values for CMT, CRT, TR, and SFCT in the PP group compared to the GP group (P < 0.05). Pearson correlation analysis revealed a positive association between postoperative visual acuity and these OCT parameters. Logistic regression modeling identified CMT, CRT, TR, and SFCT as key predictors of poor visual prognosis in AMD patients with cataract. ROC analysis showed that combining these parameters improved the prediction accuracy, with an area under the curve (AUC) of 0.993, sensitivity of 99.87%, and specificity of 95.30%, which were significantly higher compared to single-index evaluations (P < 0.05). Conclusion CMT, CRT, TR, SFCT are obviously related to the postoperative visual prognosis in patients with AMD complicated by cataract. The combined evaluation of these OCT parameters demonstrates high predictive efficiency for poor postoperative visual prognosis and can serve as an important assessment index for evaluating the postoperative visual prognosis in this patient population. |
| format | Article |
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| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-12d4c8c52e504ae2bb8a2afa581a4c072025-08-20T03:09:35ZengBMCBMC Ophthalmology1471-24152025-05-012511910.1186/s12886-025-04094-9Correlation analysis between OCT evaluation and postoperative visual prognosis of patients with age-related macular degeneration complicated with cataractLei Zhang0Yuanxiang Luo1Department of ophthalmology, The First Affiliated Hospital of Shihezi University, Xinjiang Uygur Autonomous RegionDepartment of ophthalmology, Chengdu Fifth People’s HospitalAbstract Objective To explore the correlation between optical coherence tomography (OCT) evaluations and postoperative visual prognosis in individuals with AMD complicated with cataract, and to investigate the clinical applications of these evaluations for predicting visual outcomes. Methods We retrospectively analyzed the clinical data of 132 individuals (132 eyes) with AMD complicated by cataract, admitted to our hospital from April 2022 to January 2024. All patients underwent surgical treatment and were categorized into two groups based on their visual prognosis after 6 months: the “good prognosis (GP)” group (best corrected visual acuity decrease < 0.1 logMAR) and the “poor prognosis (PP)” group (best corrected visual acuity decrease ≥ 0.1 logMAR). We evaluated OCT parameters including central retinal thickness (CRT), central macular thickness (CMT), subfoveal choroidal thickness (SFCT), and total average macular thickness (TR). Pearson correlation analysis was employed to assess the relationship between these OCT parameters and postoperative visual outcomes. Additionally, receiver operating characteristic (ROC) were used to calculate the predictive value of OCT measurements for identifying poor postoperative visual prognosis in this patient cohort. Results Preoperative OCT results showed significantly higher values for CMT, CRT, TR, and SFCT in the PP group compared to the GP group (P < 0.05). Pearson correlation analysis revealed a positive association between postoperative visual acuity and these OCT parameters. Logistic regression modeling identified CMT, CRT, TR, and SFCT as key predictors of poor visual prognosis in AMD patients with cataract. ROC analysis showed that combining these parameters improved the prediction accuracy, with an area under the curve (AUC) of 0.993, sensitivity of 99.87%, and specificity of 95.30%, which were significantly higher compared to single-index evaluations (P < 0.05). Conclusion CMT, CRT, TR, SFCT are obviously related to the postoperative visual prognosis in patients with AMD complicated by cataract. The combined evaluation of these OCT parameters demonstrates high predictive efficiency for poor postoperative visual prognosis and can serve as an important assessment index for evaluating the postoperative visual prognosis in this patient population.https://doi.org/10.1186/s12886-025-04094-9Age-related macular degeneration with cataractOptical coherence tomographyPostoperative visionPrognosis |
| spellingShingle | Lei Zhang Yuanxiang Luo Correlation analysis between OCT evaluation and postoperative visual prognosis of patients with age-related macular degeneration complicated with cataract BMC Ophthalmology Age-related macular degeneration with cataract Optical coherence tomography Postoperative vision Prognosis |
| title | Correlation analysis between OCT evaluation and postoperative visual prognosis of patients with age-related macular degeneration complicated with cataract |
| title_full | Correlation analysis between OCT evaluation and postoperative visual prognosis of patients with age-related macular degeneration complicated with cataract |
| title_fullStr | Correlation analysis between OCT evaluation and postoperative visual prognosis of patients with age-related macular degeneration complicated with cataract |
| title_full_unstemmed | Correlation analysis between OCT evaluation and postoperative visual prognosis of patients with age-related macular degeneration complicated with cataract |
| title_short | Correlation analysis between OCT evaluation and postoperative visual prognosis of patients with age-related macular degeneration complicated with cataract |
| title_sort | correlation analysis between oct evaluation and postoperative visual prognosis of patients with age related macular degeneration complicated with cataract |
| topic | Age-related macular degeneration with cataract Optical coherence tomography Postoperative vision Prognosis |
| url | https://doi.org/10.1186/s12886-025-04094-9 |
| work_keys_str_mv | AT leizhang correlationanalysisbetweenoctevaluationandpostoperativevisualprognosisofpatientswithagerelatedmaculardegenerationcomplicatedwithcataract AT yuanxiangluo correlationanalysisbetweenoctevaluationandpostoperativevisualprognosisofpatientswithagerelatedmaculardegenerationcomplicatedwithcataract |