Features of Breast Cancer Progression after Comprehensive Treatment, Prognosis of Metastatic Spread
Introduction. The effectiveness of breast cancer treatment is directly related to the absence of metastatic spread after comprehensive treatment. Still, there are no clear criteria and algorithms for predicting the occurrence of this complication. The aim of the study. To find out the features o...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Publishing House "Kyrylytsya"
2025-06-01
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| Series: | Львівський клінічний вісник |
| Subjects: | |
| Online Access: | https://lcb-journal.com/index.php/journal/article/view/457 |
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| Summary: | Introduction. The effectiveness of breast cancer treatment is directly related to the absence of metastatic spread after comprehensive treatment. Still, there are no clear criteria and algorithms for predicting the occurrence of this complication.
The aim of the study. To find out the features of the course of breast cancer, after complex treatment, and the prognosis of metastatic spread.
Materials and methods. A retrospective analysis of 701 outpatient charts of patients with breast cancer after comprehensive treatment was conducted. The informativeness of the indicators and diagnostic coefficients was determined by the method S. Kulbak (1978).
Results. Metastatic spread of breast cancer occurs in stage III disease, luminal-B, Her/2new+, and triple-negative tumor types. It is characterized by a larger tumor size and a longer history of the disease. According to calculations of the informativeness of the criteria for predicting metastatic spread of breast cancer, the above-mentioned signs have the highest diagnostic coefficient.
Conclusions. Stage III breast cancer with luminal-B, Her/2new+, triple-negative tumor types is characterized by metastatic spread, after complex treatment. Metastatic spread of breast cancer is characterized by the predominance of the size of the primary neoplasm and the duration of the disease history. An expert system was built to predict the metastatic spread of breast cancer using the following prognostic criteria: active proliferation marker, duration of the disease history, progesterone receptor expression, size of the primary neoplasm, estrogen receptor expression, epidermal growth factor Her/2new, regional lymph nodes (N2, N1), the specificity and sensitivity of which are respectively (Se = 69.0 %, Sp = 69.0 %). |
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| ISSN: | 2306-4269 2520-2898 |